A 3T Scanner for Establishing UM MPRC Neuroimaging Research Facility

描述(由申请者提供)：项目概要：本申请申请资金购买3T扫描仪系统，以在马里兰大学(UM)系统建立一个专门研究的神经成像设施。这是对恢复法有限竞争(S10)PAR-09-118的回应。我们建议在马里兰精神病学研究中心(MPRC)安装该设施。MPRC位于密歇根大学校园的中心位置。MPRC有住院和门诊精神病学研究单位，是一个提供独特的临床和协作研究机会的地方。它为研究严重精神疾病的认知增强和减轻症状的新型药物化合物提供了机会，并为难治性精神疾病进行住院神经成像研究。它将为我们广泛的新型化合物临床试验提供成像终点测量，由于缺乏现场扫描仪，目前大多数试验仅限于行为测量和临床评级。这也将是密歇根大学校园可用的第一台专用脑部研究扫描仪。该设施将为四个校区的调查人员提供服务：UM巴尔的摩和UMB医学院(UMB，UMSOM)、UM巴尔的摩县(UMBC)、UM学院公园(UMCP)和MPRC。MPRC就在密歇根大学校区的正对面，相对于其他校区位于中心位置，很容易到达。目前，密歇根大学四个校区的成像相关研究包括多个系。有一大批高级调查人员的神经成像项目目前正在外部成像设施进行。密歇根大学校园内脑成像研究人员最集中的地方是MPRC。这些研究人员拥有丰富的成像经验，包括结构、功能和化学磁共振技术，因此为所有校园的用户提供了一个支持性环境。我们还有一批处于神经成像研究培训早期和后期的初级研究人员，他们将从专门的研究设施中受益匪浅。总体而言，这一独特的安排将发挥两个重要作用：1)为严重精神疾病的住院和临床试验提供神经成像研究，否则如果没有现场扫描仪，这些研究是不可能的；2)极大地加强密歇根大学校区内已经相当可观的临床和转化神经科学工作。这一设施将大大推进正在进行的和未来由NIH资助的成像研究的科学目标。我们有一个详细的、随时可执行的安装和运行计划，其中包括复杂的硬件和软件专业知识和支持，以及我们机构的全面承诺。该项目如果获得资金，将在与购买相关的销售、建筑和维护行业提供大量美国就业机会。一旦建成，该设施将极大地促进与科学相关的就业机会的创造和保留。0

DESCRIPTION (provided by applicant): Project summary: This application requests funds to purchase a 3T scanner system to establish a research-dedicated neuroimaging facility at the University of Maryland (UM) System. This is in response to the Recovery Act Limited Competition (S10) PAR-09-118. We propose to install the facility at the Maryland Psychiatric Research Center (MPRC). The MPRC is centrally located among the UM campuses. MPRC has both inpatient and outpatient psychiatric research units and is a location that offers unique clinical and collaborative research opportunities. It provides an opportunity to study novel pharmacological compounds for cognitive enhancement and symptom reduction in severe mental illnesses and conduct inpatient neuroimaging research for treatment-resistant mentally ill. It will enable imaging endpoint measures for our extensive novel compound clinical trials, most of which are currently limited to behavioral measures and clinical ratings due to the lack of an onsite scanner. This will also be the first dedicated brain research scanner available for the UM campuses. The facility will serve investigators at four campuses: UM Baltimore and UMB School of Medicine (UMB, UMSOM), UM Baltimore County (UMBC), UM College Park (UMCP), and MPRC. The MPRC is directly across the street from the UMBC campus and centrally located relative to the other campuses and is easily accessible. Current imaging-related research at the four UM campuses includes multiple departments. There is a substantial group of senior investigators with neuroimaging projects that are currently being conducted at outside imaging facilities. The highest concentration of brain imaging investigators across UM campuses is located at the MPRC. These researchers have extensive imaging experience that includes structural, functional, and chemical MR techniques, thus providing a supportive environment for users from all campuses. We also have a group of junior investigators in early and late stages of neuroimaging research training who would greatly benefit from a dedicated research facility. Overall, the unique arrangement will serve two important functions: 1) Enable neuroimaging research for inpatient and clinical trials in severe mental illnesses that would otherwise be impossible without an onsite scanner; and 2) Greatly enhance the already substantial clinical and translational neuroscience efforts across the UM campuses. This facility will significantly advance the scientific goals of ongoing and future NIH funded imaging studies. We have a detailed and ready-to-execute plan for installation and operation that includes sophisticated hardware and software expertise and support, and a full commitment from our institutions. This project, if funded, will provide a substantial number of American jobs in sales, construction, and maintenance sectors associated with the purchase. Once it is in place, the facility will substantially facilitate science related job creation and retention. 0