DESIGN, RANDOMIZATION AND ANALYSIS CORE

随机化和分析核心（核心D）的重点是赋予我们的科学研究人员， 一流的统计推理和分析支持，以确保成功实施 和分析拟议的经验团（EC）试验。它的具体目标是履行四项关键职能。 首先，核心将支持EC学校和老年人随机化的设计和实施 志愿者第二，它将提供协调一致的统计支持，以有效地实现这一目标。 通过与所有项目中的研究人员合作设计统计分析和 标准化多个项目共享的高级分析的应用。第三，它将作为一个 知识伙伴关系和定量资源，为其他EC核心，协助招聘和 保留核心（Core B）对招聘、保留和招聘的有效性的评估 针对不同亚组的信息和策略;协助数据收集和管理 核心（核心C）的质量控制分析和分析数据集的开发;并为 行政核心（核心A）和项目调查人员对 具体研究。最后，通过与Core，C合作，Core D将支持数据安全的需求， 监测委员会通过分析不良事件和及时提供适当的数据。通过 我们将为这一项目引入大量专门的统计专业知识、基础设施和人员， 能够克服社区试验给统计分析带来的严重挑战， 提高我们获得地方和国家所需的关键证据的能力， 我们的计划将扩大规模，以改善我们老年人的健康，并支持我们孩子的成功。

The Randomization and Analysis Core (Core D) is focused on empowering our scientific investigators with first-rate statistical reasoning and analytic support that are needed to ensure the successful implementation and analysis of the proposed Experience Corps (EC) Trials. It specifically aims to perform four key functions. First, the Core will support for the design and Implementation of randomization of EC schools and older adult volunteers. Second it will provide coordinated statistical support for validly addressing the aims of this Program Project by collaborating with investigators in all projects in the design of statistical analyses and standardizing the application of high-level analyses shared by multiple projects. Third, it will serve as an intellectual partnership and quantitative resource for other EC cores by assisting the Recruitment and Retention Core (Core B)'s evaluation of the effectiveness of recruitment, retention, and recruitment messages and strategies targeting different subgroups; assisting with the Data Collection and management Core (Core C)'s quality control analyses and development of analytic datasets; and contributing to the collective understanding by the Administrative Core (Core A) and project investigators of the results from specific studies. Finally, in collaboration with Core, C, Core D will support the needs of the Data safety and Monitoring Board by analysis of adverse events and provision of appropriate data in a timely manner. By bringing in a critical mass of dedicated statistical expertise, infrastructure, and staffing to this project, we will be able to overcome the serious challenges that community trials poses for statistical analysis and hence improve our ability to derive critical evidence that is needed locally and nationally to take a high quality program to scale to improve the health of our senior citizens and support the success of our children.