Nfib regulates glial differentiation during development and disease via repression of the key epigenetic protein, Ezh2

神经胶质细胞的发育在发育过程中至关重要，成年人神经胶质干细胞的无限制增殖可导致致命的脑癌，如神经胶质瘤。目前还没有治愈胶质瘤的方法，目前的治疗方法也不能显著延缓肿瘤的进展。Nfib是一种转录因子，可以通过细胞分化阻止肿瘤生长。我们将研究Nfib在神经胶质瘤的发展和发病机制中的作用及其作为治疗靶点的潜力。

Glial development is critical during development, and unrestrained proliferation of glial stem cells in the adult can lead to deadly brain cancers such as glioma. At present there is no cure for glioma and current treatments do not significantly delay tumour progression. Nfib is a transcription factor that may prevent tumour growth through cellular differentiation. We will investigate the role of Nfib during development and in the pathogenesis of glioma and its potential as a therapeutic target.