FMRI DURING AFFECTIVE STIMULI IN PERSONALITY DISORDER PATIENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 情感不稳定是多种人格障碍的核心特征之一。这是一种情绪症状，即使在没有轴I情感障碍的情况下也可以存在，但它可以使人非常虚弱。情感不稳定似乎是一种在家庭中存在的特征，与胆碱能系统的反应性增强有关。在我们实验室的一项研究中（Steinberg et al 1995），边缘型人格障碍（BPD）患者对毒扁豆碱的抑郁反应比正常对照组更强，而其他人格障碍患者与正常对照组无差异。 最近的神经影像学研究（Herpertz，S. C.的方法，T. M. Dietrich等人（2001））。已经表明，与健康对照组相比，BPD患者在观看引起负面情绪的图片时，杏仁核和其他区域的活动增加。本研究旨在扩展他的工作，以研究BPD患者活动增加的可能机制。我们将研究两种可能的机制：（1）BPD患者未能习惯于负面情绪刺激;（2）BPD患者未能利用有意识的认知策略来调节他们的情绪反应。对全球区域中心成像核心支持的这一请求旨在为计划提交的外部供资开发试点数据。过去，该研究者成功地使用GCRC支持的试点成像数据，获得了NIH资助，用于精神分裂症谱系中的工作记忆研究（1 RO 1 MH 069947 - 01 A1）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Affective instability is one of the core features of a variety of personality disorders. It is a mood symptom that can be present even in the absence of an axis I affective disorder, yet it can be highly debilitating. Affective instability appears to be a trait that runs in families and is associated with a heightened responsiveness of the cholinergic system. In a study in our laboratory (Steinberg et al 1995), borderline personality disorder (BPD) patients showed a greater depressive response to physostigmine than normal controls, while other personality disorder patients did not differ from the normal controls. More recently neuroimaging studies (Herpertz, S. C., T. M. Dietrich, et al. (2001)). have shown that BPD patients show increased activity in the amygdale and other regions compared to healthy controls while viewing negative emotion inducing pictures. The present study is designed to extend his work to investigate possible mechanisms for the increased activity in BPD patients. We will examine two possible mechanisms: (1) failure of BPD patients to habituate to negative emotional stimuli and (2) failure of BPD patients to utilize conscious cognitive strategies to modulate their emotional reactions. This request for GCRC imaging core support is intended to develop pilot data for a planned submission for external funding. In the past this investigator was successful in using GCRC supported pilot imaging data to obtain NIH funding for a study of working memory in the schizophrenia spectrum (1RO1 MH069947-01A1).