FMRI DURING AFFECTIVE STIMULI IN PERSONALITY DISORDER PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。情感不稳定是各种人格障碍的核心特征之一。这是一种情绪症状，即使在没有I轴情感障碍的情况下也会出现，但它可能会使人非常虚弱。情感不稳定似乎是一种家族遗传特征，与胆碱能系统的高反应性有关。在我们实验室的一项研究中（Steinberg et al 1995），边缘型人格障碍（BPD）患者比正常对照者表现出更大的抑郁反应，而其他人格障碍患者与正常对照者没有差异。最近的神经影像研究（Herpertz, s.c., t.m. Dietrich, et al.(2001)）。研究表明，与健康对照组相比，BPD患者在观看负面情绪诱导图片时，杏仁核和其他区域的活动增加。目前的研究旨在扩展他的工作，以调查BPD患者活动增加的可能机制。我们将研究两种可能的机制：(1)BPD患者未能适应负面情绪刺激；(2)BPD患者未能利用有意识的认知策略来调节他们的情绪反应。这项关于GCRC成像核心支持的请求旨在为计划提交的外部资助开发试点数据。在过去，该研究者曾成功地利用GCRC支持的试点成像数据获得NIH资助，用于研究精神分裂症谱系中的工作记忆（1RO1 MH069947-01A1）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Affective instability is one of the core features of a variety of personality disorders. It is a mood symptom that can be present even in the absence of an axis I affective disorder, yet it can be highly debilitating. Affective instability appears to be a trait that runs in families and is associated with a heightened responsiveness of the cholinergic system. In a study in our laboratory (Steinberg et al 1995), borderline personality disorder (BPD) patients showed a greater depressive response to physostigmine than normal controls, while other personality disorder patients did not differ from the normal controls. More recently neuroimaging studies (Herpertz, S. C., T. M. Dietrich, et al. (2001)). have shown that BPD patients show increased activity in the amygdale and other regions compared to healthy controls while viewing negative emotion inducing pictures. The present study is designed to extend his work to investigate possible mechanisms for the increased activity in BPD patients. We will examine two possible mechanisms: (1) failure of BPD patients to habituate to negative emotional stimuli and (2) failure of BPD patients to utilize conscious cognitive strategies to modulate their emotional reactions. This request for GCRC imaging core support is intended to develop pilot data for a planned submission for external funding. In the past this investigator was successful in using GCRC supported pilot imaging data to obtain NIH funding for a study of working memory in the schizophrenia spectrum (1RO1 MH069947-01A1).