ANGER EXPRESSION, EDNOGENOUS OPHOIDS, AND ACUTE PAIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的具体目的是确定愤怒唤醒是否是阿片类药物功能障碍和愤怒与疼痛敏感性之间出现联系的关键因素。健康的正常人将被分配到安慰剂或阿片类药物阻断(50毫克纳曲酮)的条件下，并将执行一项认知任务，先进行骚扰，然后进行疼痛诱导，或者进行疼痛诱导，然后进行认知任务。如果愤怒唤醒是导致阿片类药物介导的与愤怒相关的疼痛敏感度差异的关键决定因素，那么我们预计愤怒x药物x任务顺序交互作用如下：a)在安慰剂下，高愤怒将与更高的疼痛敏感性相关，在疼痛诱导之前经历骚扰(即愤怒诱导)的受试者中最强烈；b)药物阻断低愤怒个体潜在的内源性阿片类药物疼痛反应减弱将导致愤怒和疼痛敏感性之间的关系对于两个任务顺序都变得不显著。综上所述，在急性愤怒唤醒的条件下，药物阿片类药物阻断有望使低愤怒个体对疼痛刺激的反应类似于高愤怒个体，后者预计会表现出阿片类药物功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Specific Aim of the study is to determine whether anger arousal is a key factor in the emergence of the link between opioid dysfunction and anger-out vis-a-vis pain sensitivity. Healthy normals will be assigned to placebo or opioid blockade (50 mg naltrexone) conditions and will perform either a cognitive task with harassment followed by pain-induction, or will undergo pain induction and then the cognitive task. If anger arousal is a key determinant in eliciting opioid-mediated differences in pain sensitivity associated with anger-out, then we expect anger-out x drug x task order interactions such that: a) under placebo, high anger-out will be related to greater pain sensitivity most strongly among subjects undergoing harassment (i.e. anger induction) prior to pain-induction; b) pharmacological blockade of the endogenous opioids underlying diminished pain responsiveness in low anger-out individuals will result in the relationships between anger-out and pain sensitivity becoming nonsignificant for both task orders. In summary, under conditions of acute anger arousal, pharmacological opioid blockade is expected to make low anger-out individuals react to pain stimulation in a manner similar to high anger-out individuals, who are expected to display opioid dysfunction.