A Patient-Oriented Research Mentoring Program in Tobacco Dependence Research

尽管过去50年来在降低吸烟率方面取得了很大进展，但烟草依赖仍然是一个严重的问题。 美国最大的公共卫生问题。确保持续和有影响力的研究工作，致力于 为了解决烟草依赖问题，需要制定严格的跨学科指导计划， 下一代研究人员致力于烟草依赖患者导向研究（POR）。我有 领导了一个成功的研究计划，重点是评估方法，以提高使用和有效性 大约20年来，我一直致力于尼古丁依赖的治疗，在此期间，我指导了24名学生， 研究员或初级教员。该中期职业研究者奖将用于支持2个总体职业生涯 目标.首先，为了支持我的主要指导职业目标，我将正式化并加强指导 我自2001年以来一直从事的活动，变成了一个结构化的，全面的，有影响力的指导 计划在烟草依赖POR的学生，研究员和初级教师。这将涉及：1） 为不同学术水平的受训者实施正式的指导框架， 与过去5年相比，学员人数显著增加， 出版物和赠款; 2）通过新机制， 作为T32和TCORS; 3）招聘和指导6名学生，4名研究员和3名初级教师， 未来5年，除了5名目前的学员（共18人）。我的指导计划将使用NIDA的 指导框架，并将：1）侧重于学生和初级教师，以确保培训开始早， 学员的职业生涯; 2）根据学员的目标和能力提供个性化培训; 3）提供 短期/密集和长期/持续的培训取决于学员; 4）提供跨学科的培训 科学; 5）提供以患者为导向的研究（POR）的强化培训。为了促进我的职业发展， 我将：1）使用指导咨询委员会，由具有指导经验的教师组成，2）完成 课程，会议和研讨会在翻译和实施科学和指导， 领导; 3）加入宾夕法尼亚大学的努力，以加强行为和初级保健之间的联系。第二，支持 我的主要研究职业目标，我将扩大我的POR计划，包括翻译和实施 通过使用尼古丁代谢物比率（NMR）的试点研究， 在初级保健中为尼古丁依赖开处方和患者使用治疗。根据我们的工作 显示使用NMR的个性化尼古丁依赖治疗提高了治疗效果 和安全性，试点将评估这种模式在初级保健中的转化潜力，同时提供 学员培训和促进后续R 01的机会。这一职业生涯中期调查奖将 显著改善我过去的指导记录，提供新的指导和职业发展机会， 并使我的POR计划扩展到包括翻译和实施科学。

Despite great progress over the past 50 years in reducing the rate of smoking, tobacco dependence remains a leading public health concern in the US. To ensure the sustained and impactful research effort dedicated to addressing tobacco dependence, rigorous and inter-disciplinary mentoring programs are needed to prepare the next generation of researchers committed to tobacco dependence patient-oriented research (POR). I have led a successful research program focused on the evaluation of methods to improve the use and effectiveness of treatments for nicotine dependence for ~20 years and, during this time, I have mentored 24 students, fellows, or junior faculty. This Mid-Career Investigator Award will be used to support 2 overarching career goals. First, to support my primary mentorship career goal, I will formalize and enhance the mentoring activities that I have been engaged in since 2001 into a structured, comprehensive, and impactful mentoring program in tobacco dependence POR for students, fellows, and junior faculty. This will involve: 1) the implementation of a formal mentoring framework for trainees with different academic levels, which will double the number of mentees vs. the past 5 years and markedly increase mentoring productivity and impact in terms of publications and grants; 2) strengthening a pipeline for mentee recruitment through new mechanisms such as T32s and TCORS; and 3) the recruitment and mentoring of 6 students, 4 fellows, and 3 junior faculty over the next 5 years, in addition to 5 current mentees (for a total of 18). My mentoring program will use NIDA's mentoring framework, and will: 1) focus on students and junior faculty to ensure that training begins early in a mentee's career; 2) provide individualized training based on mentee's goals and abilities; 3) provide short/intensive and long/sustained traineeships depending on the mentee; 4) offer training in inter-disciplinary science; and 5) offer intensive training in patient-oriented research (POR). To facilitate my career development, I will: 1) use a Mentoring Advisory Committee, comprised of faculty experienced with mentoring, 2) complete courses, conferences, and workshops in translational and implementation science and mentoring and leadership; and 3) join a Penn effort to enhance links between behavioral and primary care. Second, to support my primary research career goal, I will broaden my POR program to include translational and implementation science through a pilot study of the use of the nicotine metabolite ratio (NMR) for promoting clinician prescribing and patient use of treatments for nicotine dependence within primary care. Based on our work showing that personalizing nicotine dependence treatment using the NMR improves treatment effectiveness and safety, the pilot will assess the translational potential of this model within primary care, while providing opportunities for mentee training and facilitating a subsequent R01. This mid-career investigator award will markedly improve my past mentoring record, offer new opportunities for mentoring and career development, and enable the expansion of my POR program to include translational and implementation science.