Aflatoxin exposure and hepatocellular carcinoma in Mexico

项目总结 黄曲霉毒素B1(AFB1)是食物中的一种真菌污染物，可能对 增加墨西哥的肝细胞癌(HCC)负担。墨西哥的肝癌流行病学是不寻常的 鉴于乙型和丙型肝炎病毒感染的低流行率，男性和 女性，以及城乡差距。在墨西哥，作为主食的玉米似乎普遍 被黄曲霉毒素污染。因此，AFB1污染单独或与非病毒风险相结合 因素可能是肝癌发病率的驱动因素。我们的目标是提供有关AFB1相关性的初步数据 在加强研究能力以满足未来需求的同时，为墨西哥的肝细胞癌提供技术援助。我们具体将(1) 测量来自四个肝癌高负荷地区的955名女性和男性的循环AFB1；以及(2) 建立一个研究网络，以追溯识别黄曲霉毒素在肝脏样本中诱导的突变 确定前瞻性地从事件中获取临床信息和生物检疫的可行性 肝细胞癌病例。我们将深入了解具有独特流行病学的人群中的肝癌危险因素 模式，展示我们访问现有生物存储库的能力，这将成为重要的 为未来的环境和癌症研究提供资源，并创造一个强有力的研究环境 这将促进未来与当地、地区和国际科学家的合作努力。

PROJECT SUMMARY Aflatoxin B1 (AFB1) is a fungal contaminant in food that may be exerting a significant impact on the increasing hepatocellular cancer (HCC) burden in Mexico. HCC epidemiology in Mexico is unusual given the low prevalence of hepatitis virus B and C infection, similar HCC mortality among men and women, and a rural-urban gradient. In Mexico, maize, a staple food, appears to be commonly contaminated by aflatoxins. Thus, AFB1 contamination alone or in combination with non-viral risk factors may be driving HCC incidence rates. We aim to provide initial data on the relevance of AFB1 for HCC in Mexico, while strengthening research capacity for future needs. We specifically will (1) measure circulating AFB1 from 955 women and men from four high HCC burden areas; and (2) create a research network to retrospectively identify aflatoxin-induced mutations in liver samples and determine the feasibility of prospectively obtaining clinical information and biospecimens from incident HCC cases. We will gain insight into HCC risk factors in a population with a unique epidemiological pattern, demonstrate our capacity to access an existing biorepository that will become an important resource for future environmental and cancer research, and create a strong research environment that will foster future collaborative efforts with local, regional, and international scientists.