Enhancing Recovery Outcomes in Alcohol Use Disorder: Cognitive Training as an Adjunct to Treatment

项目摘要/摘要 对酒精使用障碍(AUD)神经认知功能的程序性研究揭示 广泛和持续的损伤。尽管概念上与治疗效果相关，但很少有AUD 干预措施的目的是补救这些损害。拟议的K01是对 这个缺口。它将回答有关认知训练(CT)作为辅助应用的潜力的关键问题 住院治疗，改善AUD患者的认知恢复和出院后的功能结果。 刘易斯博士是职业生涯早期的认知神经学家，致力于酒精科学和 开发针对澳大利亚糖尿病的新干预措施。他的基本科学背景是为了促进 AUDS患者的禁欲情况。他的临床研究主要集中在酒精相关的研究上。 神经认知障碍。拟建的K01将有助他把这些目标融入发展计划。 一项旨在促进神经认知和功能恢复的新干预措施的研究计划。 拟议的研究和培训受益于多元化、多学科的指导团队，利用 在认知神经科学、成瘾、认知训练、计算机科学和生物统计分析方面的专业知识。 此K01奖项支持的培训将包括开发高级 纵向卫生干预的方法/分析，以及知识和技能基础的发展 人机交互理论，促进了刘易斯博士开发个性化、适应性计算机的能力- 以干预为基础。 目前的项目将在样本中调查两种实验性认知训练干预的有效性。 接受澳门氏症治疗的住院患者比例。虽然CT增强功能的有效性得到了不同方面的支持 在文献中，它在很大程度上仍未在澳元进行审查。目前的提案将质疑在多大程度上 认知训练干预可以将认知知识“转移”到未经训练的任务/领域，并提高整体水平 执行功能。它将应用CT和酒精文献中的概念模型来确定因素 与CT疗效相关。认知训练对功能结果的影响，包括出院后 饮酒，将被调查。最后，治疗期间和治疗后认知恢复之间的关系 将对出院适应进行审问。因此，拟议的工作将对公共卫生具有重大意义， 酒精科学，并将为未来的干预努力提供信息。

Project Summary/Abstract Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. The proposed K01 is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD. The PI, Dr. Lewis, is an early career cognitive neuroscientist, committed to alcohol science and the development of novel interventions for AUD. His basic science background was directed toward facilitating abstinence in individuals with AUDs. His clinical research has focused on the investigation of alcohol-associated neurocognitive perturbations. The proposed K01 will facilitate his integration of these aims into the development of a research program directed toward novel interventions promoting neurocognitive and functional recovery. The proposed research and training benefit from a diverse, multidisciplinary mentoring team, leveraging expertise in cognitive neuroscience, addiction, cognitive training, computer science, and biostatistical analysis. The training supported by this K01 award will include the development of expertise in advanced methods/analysis of longitudinal health interventions, and the development of knowledge and skill bases in human-computer interaction theory, facilitating Dr. Lewis’ ability to develop individualized, adaptive computer- based interventions. The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current proposal will question the degree to which cognitive training interventions can “transfer” cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post- discharge adaptation will be interrogated. Thus, the proposed work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.