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Enhancing Recovery Outcomes in Alcohol Use Disorder: Cognitive Training as an Adjunct to Treatment

提高酒精使用障碍的康复效果：认知训练作为治疗的辅助手段

基本信息

批准号：
10478145
负责人：
Ben Lewis
金额：
$ 11.62万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478145
关键词：
Abstinence Address Alcohol consumption Alcoholism Alcohols Attention deficit hyperactivity disorder Basic Science Biometry Clinical Research Cognitive Computers Consumption Control Groups Data Data Collection Development Distal Education Educational Intervention Effectiveness Evaluation Future Health Human Resources Impaired cognition Impairment Individual Individual Differences Inpatients Intervention Intervention Studies Interview Investigation Knowledge Literature Measures Mentored Research Scientist Development Award Mentors Methods Modeling Modification Motivation Neurocognitive Neurocognitive Deficit Outcome Participant Performance Predictive Factor Procedures Process Public Health Recovery Recovery of Function Research Research Training Response to stimulus physiology Sampling Science Self Efficacy Severities Short-Term Memory Training Training Support Treatment Efficacy Treatment outcome Work active control addiction alcohol abuse therapy alcohol craving alcohol intervention alcohol use disorder base career cognitive function cognitive neuroscience cognitive recovery cognitive training computer human interaction computer science computer studies computerized craving drinking executive function follow-up functional improvement functional outcomes improved longitudinal analysis model development multidisciplinary novel programs recruit remediation response screening sex skills substance use theories treatment arm treatment as usual treatment duration

项目摘要

Project Summary/Abstract Programmatic investigation of neurocognitive functioning in alcohol use disorder (AUD) has revealed widespread and sustained impairments. Despite conceptual relevance to treatment efficacy, few AUD interventions have been directed to the remediation of these impairments. The proposed K01 is responsive to this gap. It will answer critical questions regarding the potential of cognitive training (CT), applied as an adjunct to inpatient treatment, to improve cognitive recovery and post-discharge functional outcomes in AUD. The PI, Dr. Lewis, is an early career cognitive neuroscientist, committed to alcohol science and the development of novel interventions for AUD. His basic science background was directed toward facilitating abstinence in individuals with AUDs. His clinical research has focused on the investigation of alcohol-associated neurocognitive perturbations. The proposed K01 will facilitate his integration of these aims into the development of a research program directed toward novel interventions promoting neurocognitive and functional recovery. The proposed research and training benefit from a diverse, multidisciplinary mentoring team, leveraging expertise in cognitive neuroscience, addiction, cognitive training, computer science, and biostatistical analysis. The training supported by this K01 award will include the development of expertise in advanced methods/analysis of longitudinal health interventions, and the development of knowledge and skill bases in human-computer interaction theory, facilitating Dr. Lewis’ ability to develop individualized, adaptive computer- based interventions. The current project will investigate the efficacy of two experimental cognitive training interventions in a sample of inpatients in treatment for AUD. While the effectiveness of CT to enhance function is supported by diverse literatures, it remains largely unexamined in AUD. The current proposal will question the degree to which cognitive training interventions can “transfer” cognitive gains to untrained tasks/domains, and improve overall executive functioning. It will apply conceptual models from the CT and alcohol literatures to identify factors associated with CT efficacy. The impact of cognitive training on functional outcomes, including post-discharge drinking, will be investigated. Finally, relationships between cognitive recovery during treatment and post- discharge adaptation will be interrogated. Thus, the proposed work will be of substantial import to public health, alcohol science, and will inform future intervention efforts.

项目总结/文摘