Training Program in Translational Brain Tumor Research

项目摘要 该计划的目标是为对以下领域感兴趣的个人提供博士后和博士后培训 从事转化性脑瘤研究。尽管神经外科医生尽了最大努力，神经肿瘤学家， 而基于实验室的科学家，脑癌仍然是所有恶性肿瘤中最致命的之一。 脑癌治疗的改进进展缓慢，部分原因是个体相对匮乏。 培训方式使他们能够与临床医生和实验室调查人员进行交流。这是 T32培训助学金11-15年的续签申请 加州大学旧金山分校。加州大学旧金山分校脑瘤中心是美国最大的项目 重点是开发未来的脑肿瘤翻译型研究人员；可以移动的人 在临床和实验室之间无缝连接，这样做可以更有效地为 脑肿瘤新的治疗干预措施的发展。我们打算在培训成功的基础上再接再厉 在以前的周期中，维持受训人员和导师的数量。此应用程序请求支持 博士后和博士后培训计划(3名博士后实习生，1名博士后实习生)。这个 博士后实习生是从教师的实验室和诊所中挑选出来的，博士后实习生是从 生物医学科学项目的尖子生。该项目的教师由23名导师组成， 由19个研究实验室组成的核心实验室的工作使加州大学旧金山分校的脑肿瘤社区成为世界上 富有成效，并在世界上得到认可。在所请求的两年支持期间，受训人员 与这些实验室和诊所的PI合作，开发并完成有意义和有意义的翻译 脑肿瘤研究项目，并在此过程中流利地进行基于实验室的研究和临床研究 技巧。基础科学实习生在临床神经病理学方面也有独特的指导经验， 临床神经肿瘤学、临床试验设计和新的神经外科体验组件。在同一时间 受训者参加由教员主导的教学课程，该课程专门关注脑瘤相关问题， 允许学员发展一种共同语言来讨论和理解脑瘤生物学， 诊断和治疗方式，以及该领域尚未解决的问题。其他课程和培训 包括鼓励有效说话和写作的活动，并有广泛的选择 现有课程，帮助为个别学员量身定做教育经验。评估和指导 包括各种机制，以帮助确保项目的成功和实现未来的职业目标。这个 加州大学旧金山分校T32计划在转化性脑瘤研究中有很好的记录，吸引了合格的 个人，并成功地让研究人员准备好领导转化型脑瘤研究团队 在国内和国际上，加入到抗击脑癌的斗争中来。

Project Summary The objective of this program is to provide predoctoral and postdoctoral training for individuals interested in careers in translational brain tumor research. Despite the best efforts of neurosurgeons, neuro-oncologists, and laboratory-based scientists, brain cancer remains among the most deadly of all malignancies. Improvements in brain cancer therapy have come slowly, in part because of the relative dearth of individuals trained in a manner that allows them to communicate with both clinicians and lab-based investigators. This is a renewal application for years 11-15 of the T32 Training Grant in Translational Brain Tumor Research at the University of California San Francisco. The UCSF Brain Tumor Center is the largest program in the nation that focuses on developing translational brain tumor investigators of the future; individuals who can move seamlessly between clinical and laboratory worlds and in doing so can more effectively contribute to the development of new therapeutic interventions for brain tumors. We intend to build upon the training successes in the previous cycles, maintaining the number of trainees and mentors. This application requests support for a postdoctoral and predoctoral Training Program (three postdoctoral trainees, 1 predoctoral trainees). The postdoctoral trainees are selected from the labs and clinics of the faculty, and the predoc trainee is drawn from the top-tier students in the Biomedical Sciences Program. The faculty of the Program consists of 23 mentors, and a core of 19 research labs whose work has made the UCSF brain tumor community one of the most productive and recognized in the world. Over the course of the two years of support requested, the trainees work with the PIs of these labs and clinics to develop and complete meaningful and significant translational brain tumor research projects, and in the process become fluent in laboratory-based and clinical research techniques. The basic science trainees also have unique, supervised experiences in clinical neuropathology, clinical neuro-oncology, clinical trial design and a new neurosurgery experience component. At the same time trainees take part in a faculty-led didactic curriculum uniquely focused on brain tumor-related issues and which allow trainees to develop a common language with which to discuss and understand brain tumor biology, diagnostic and therapeutic modalities, and unresolved problems in the field. Additional courses and training events that encourage effective speaking and writing are included, and there is an extensive selection of existing courses to help tailor the educational experience of individual trainees. Evaluation and mentoring mechanisms are included to help ensure success in the program and in attaining future career goals. The UCSF T32 Program in Translational Brain Tumor Research has a strong track record of attracting well-qualified individuals, and in successfully preparing investigators to lead translational brain tumor research teams nationally, and internationally, and joining in the fight against brain cancer.