Administrative Core

摘要 骨感染骨免疫学研究翻译中心（CoRTOBI）是 两个非常成功的项目（AOTrauma骨感染临床优先项目）的发展 （AO-CPP）;和NIAMS P50 CORT AR54041“Translating Molecular Signal Pathways to Orthoprotoxin 创伤护理”），由罗切斯特大学的多学科研究小组管理 肌肉骨骼研究中心。为了充分利用这些方案的突出优势， CoRTOBI现在建议推进基础和转化科学技术发现 从S.金黄色葡萄球菌感染的骨和宿主免疫力，使用证明行政 P50 CORT的结构在这样做时，拟议的CoRTOBI行政核心将汇集 微生物发病机理和遗传学、抗生素药物发现、材料科学、 组织工程学、免疫学、骨病理学、生物统计学和矫形外科， 致力于改善骨髓炎患者的预防、诊断和治疗。 行政核心将提供CORTOBI的业务和财政管理。它还将 支持项目和研究核心的临床研究和生物统计需求，促进 通信，运行浓缩计划，并实施试点和可行性项目计划。 博士爱德华施瓦茨将担任主任。他将得到哈尼博士奖（助理）的协助 主任）、Stephen Kates博士（临床研究子核心主任）和Christopher Beck博士 （生物统计分中心主任）。这些董事将由指导委员会、 内部咨询委员会（IAB）和外部咨询委员会（EAB）。 行政核心的具体目标是： 目标1.管理整个CoRTOBI，包括人事管理、财务监督， 并透过定期会议的评估，对服务和研究进度进行质素控制。 目标2.促进CoRTOBI项目和核心调查员、IAC和EAC、我们的 NIH资助CTSA，NIH/NIAMS计划工作人员和更大的科学界。 目标3。协调对HBMI和BBMTI核心的经济有效的访问， 罗切斯特资源型肌肉骨骼生物学与医学中心; NIAMS P30 AR 069655。 目标4。建立骨感染试点和可行性项目计划（PFPP）， 我们的CTSA和NIAMS P30试点项目计划。 目标5。为CoRTOBI研究者、骨感染研究者、 整形外科医生，以及更大的科学和外行社区。

Abstract The Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI) is the evolution of two highly successful programs (AOTrauma Clinical Priority Program on Bone Infection (AO-CPP); and NIAMS P50 CORT AR54041 “Translating Molecular Signal Pathways to Orthopaedic Trauma Care”), which are run by multidisciplinary teams of investigators in the University of Rochester Center for Musculoskeletal Research. To capitalize on the salient strengths of these programs, the CoRTOBI now proposes to advance the basic and translational scientific and technological discoveries from the AO-CPP on S. aureus infection of bone and host immunity, using the proven administrative structure of the P50 CORT. In so doing, the proposed CoRTOBI Administrative Core will bring together renowned experts in microbial pathogenesis & genetics, antibiotic drug discovery, material science, tissue engineering, immunology, bone pathology, biostatistics and orthopaedic surgery, who are dedicated to the goals of improved prevention, diagnosis, and treatments for osteomyelitis patients. The Administrative Core will provide operational and fiscal management of the CoRTOBI. It will also support the clinical research and biostatistical needs of the Projects and Research Core, facilitate communications, run the enrichment programs, and implement a Pilot and Feasibility Project Program. Dr. Edward Schwarz will serve as the Director. He will be assisted by Dr. Hani Award (Associate Director), Dr. Stephen Kates (Director of the Clinical Research Sub-Core), and Dr. Christopher Beck (Director of the Biostatistics Sub-Core). These Directors will be advised by a Steering Committee, an Internal Advisory Committee (IAB), and an External Advisory Committee (EAB). The Specific Aims of the Administrative Core are to: Aim 1. Govern the entire CoRTOBI, which includes administration of personnel, financial oversight, and quality controls on services and research progress through evaluations at scheduled meetings. Aim 2. Foster communications between CoRTOBI Project & Core investigators, the IAC & EAC, our NIH funded CTSAs, NIH/NIAMS Program staff, and the greater scientific community. Aim 3. Coordinate cost-effective access to the HBMI and BBMTI Cores supported by The University of Rochester Resource-Based Center for Musculoskeletal Biology & Medicine; NIAMS P30 AR069655. Aim 4. Establish a Pilot and Feasibility Project Program (PFPP) in Bone Infection that will synergize with our CTSAs and NIAMS P30 Pilot Project Programs. Aim 5. Provide enrichment opportunities for CoRTOBI investigators, bone infection researchers, orthopaedic surgeons, and the larger scientific and lay communities.