Core 1: Biostatistics Core

项目摘要 胃肠道生物统计学和生物信息学核心（GI-BBC）的目标是 为地理信息系统提供广泛、高质量的统计和生物信息学支持 孢子。GI-BBC的主要目的是协助GI SPORE调查人员 本SPORE中提议的实验室和临床研究的设计、实施和分析 应用程序.英国广播公司将集中精力协助临床和实验室 研究者将其临床前研究转化为临床研究， 最先进的实验设计和分析，通过统计咨询， 在方法、可行性、分析和临床报告方面的合作 和实验室研究。此外，GI-BBC将作为所有人的持续资源， GI-SPORE调查员。核心将由Sugar博士、Scharpf博士和Scharpf博士领导。 Rachel Karkin将担任联合调查员。这些GI-BBC教职员工拥有 互补的专业领域：Sugar博士在生物统计学方面专门从事翻译 和临床研究设计和分析，Scharpf博士在高通量分析 基因组分析，计算遗传学的卡钦博士阿曼达布莱克福德女士a 癌症中心的生物统计学家将协助Sugar和Scharpf博士进行统计。 分析。大卫麦基恩，硕士水平的生物信息学专家将协助博士。 沙尔夫将统计需求集中在GI-BBC核心内， 调查人员可以公开接触到一个具有必要技能的统计人员团队， 以具有成本效益的方式满足SPORE当前和未来的目标。此外，本发明还提供了一种方法， 它将促进整个SPORE项目之间的交流，帮助翻译研究成果 将研究结果应用于临床。

PROJECT SUMMARY The goal of the GastroIntestinal Biostatistics and Bioinformatics Core (GI-BBC) is to provide wide-ranging, high-quality statistical and bioinformatics support to the GI SPORE. The primary aim of the GI-BBC is to assist GI SPORE investigators in the design, conduct and analysis of laboratory and clinical studies proposed in this SPORE application. The GI-BBC will focus its efforts on assisting both the clinical and laboratory investigators in translating their pre-clinic studies into clinical studies by providing state- of-the-art experimental designs and analyses through statistical consultation and in collaboration with respect to methodology, feasibility, analysis, and reporting of clinical and laboratory studies. In addition, the GI-BBC will serve as an ongoing resource for all GI-SPORE investigators. The Core will be led by Dr. Sugar and Dr. Scharpf and Dr. Rachel Karchin will act as a co-investigator. These GI-BBC faculty members have complementary areas of expertise: Dr. Sugar in biostatistics specializing in translation and clinical study design and analysis, Dr. Scharpf in the analysis of high-throughput genomic assays, Dr. Karchin in computational genetics. Ms. Amanda Blackford, a biostatistician in the Cancer Center, will assist Drs. Sugar and Scharpf in statistical analyses. David McKean, a Master's level bioinformatics specialist will assist Dr. Scharpf. Centralization of statistical needs within the GI-BBC core will provide SPORE investigators with open access to a team of statisticians with the skill set necessary to meet the current and future goals of the SPORE in a cost-effective manner. In addition, it will facilitate communication across SPORE projects, aiding the translation of research findings into the clinical setting.