Core E: Biostatistics & Informatics Core

生物统计和信息学(BI)核心的首要目标是提供高质量和最新的 在生物统计和信息学方面为西尼苏岛所有研究项目和数据生成核心提供艺术服务 加味烟草产品研究中心(克罗夫特)。商业智能核心将提供具有成本效益的 为适当的研究设计、数据收集、安全数据传输、数据质量控制提供集中服务， 数据协调、数据库管理、生物统计和生物信息数据分析、结果 解释和报告，以及新的生物统计和生物信息方法和工具的开发， 和训练。核心负责人李博士和两位核心合作调查员麦考尔博士和严博士拥有广泛的 生物统计学和生物信息学方面的经验，包括研究设计、数据收集、数据质量控制、 横截面和纵向数据分析、DNA甲基化和基因表达数据分析 生物统计学和生物信息学方法和工具的开发。BI核心将通过 以下是具体目标： 目标1：为正在进行的项目和试点项目提供研究设计支持。BI核心将为RAPID提供支持 克罗夫特内部的响应和职业提升试点项目，以确保适当的研究设计方法 通过能量分析得到了足够的样本量。此外，BI核心将为调查人员提供建议 对最大限度地减少自然减员和最大限度地增加参与的程序进行纵向研究。 目标2：数据采集、质量保证和协调。BI核心将建立一个Croft数据库以 收集项目和岩心产生的所有数据，执行数据质量控制程序，以确保高 数据质量，并通过PhenX工具包进行数据协调，以促进数据在 所有烟草调控科学中心(TCORS)。 目标3：统计和生物信息数据分析、新方法和工具开发。BI核心 将标准化基因组数据分析的生物统计和生物信息学方法和工具，提供 流行病学数据分析用于确定与人类有关的新出现的香料化合物的风险 健康，并为综合数据开发尖端的新生物统计和生物信息方法和工具 跨项目进行分析，对风味风险进行分类。 目的4.统计和生物信息学方法和工具培训。商业智能核心将促进传播 通过公开向所有TCORS研究人员提供新的生物统计学和生物信息学方法和工具 无障碍研讨会、座谈会和研讨会。 BI核心还将与管理核心(AC)和职业提升核心(CEC)合作，并利用 罗切斯特大学临床与翻译科学研究所内的资源，以提供强大的 以及对烟草产品监管科学的集中支持。

The overarching goal of the Biostatistics and Informatics (BI) Core is to provide high quality and state-of-the- art services in biostatistics and informatics to all research projects and data generating cores within the WNY Center for Research on Flavored Tobacco Products (CRoFT). The BI core will provide cost-efficient and centralized service for appropriate study design, data collection, secured data transfer, data quality control, data harmonization, database management, biostatistical and bioinformatical data analysis, results interpretation and reporting, as well as novel biostatistical and bioinformatical methods and tools development, and training. The core lead Dr. Li and two core co-investigators Drs. McCall and Yan have extensive experiences in biostatistics and bioinformatics, including study design, data collection, data quality control, cross-sectional and longitudinal data analysis, DNA methylation and gene expression data analysis, novel biostatistical and bioinformatical methods and tools development. The BI core will achieve the goal through the following specific aims: Aim 1: Study design support for ongoing and pilot projects. The BI core will provide support to rapid response and career enhancement pilot projects within CRoFT to ensure appropriate research design methods and adequate sample size resulted from power analysis. In addition, the BI core will advise investigators conducting longitudinal studies on procedure for minimizing attrition and maximizing participation. Aim 2: Data capture, quality assurance and harmonization. The BI core will set up a CRoFT database to capture all data generated from projects and cores, conduct data quality control procedures to ensure the high quality of the data, and conduct data harmonization through PhenX Toolkit to facilitate the data sharing across all Tobacco Centers of Regulator Science (TCORS). Aim 3: Statistical and bioinformatical data analysis, novel methods and tools development. The BI core will standardize biostatistical and bioinformatical methods and tools for genomic data analysis, provide epidemiological data analysis for identifying risks of emerging flavoring compounds associated with human health, and develop cutting-edge novel biostatistical and bioinformatical methods and tools for integrated data analysis across projects to categorize flavor risks. Aim 4. Statistical and bioinformatical methods and tools training. The BI core will promote dissemination of the novel biostatistical and bioinformatical methods and tools to all TCORS investigators through publicly accessible seminars, symposia, and workshops. The BI core will also partner with Administrative Core (AC) and Career Enhancement Core (CEC) and leverage the resources within the University of Rochester Clinical and Translations Science Institute to provide robust and centralized support to tobacco product regulator science.