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Advanced Development of Inhibitors of human Lactate Dehydrogenase A (LDHA) as Anticancer Agents (Chemical Biology Consortium/NCI Experimental Therapeutics Collaboration)

Advanced Development of Inhibitors of human Lactate Dehydrogenase A (LDHA) as Anticancer Agents (Chemical Biology Consortium/NCI Experimental Therapeutics Collaboration)
人类乳酸脱氢酶 A (LDHA) 抑制剂作为抗癌药物的先进开发（化学生物学联盟/NCI 实验治疗合作组织）
批准号：
10255282
负责人：
Matthew Hall
金额：
$30.57万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10255282
关键词：
Advanced DevelopmentAntineoplastic AgentsBiologyBiotechnologyCell divisionChemicalsCollaborationsDrug TargetingEnzymesExhibitsHumanInvestigational TherapiesLicensingMediationMetabolicPathway interactionsPreparationPublicationsReactionResearchTechnologyWorkanti-cancercancer cellcancer typecell growthin vitro activityin vivoinhibitor/antagonistlactate dehydrogenase Amodel developmentnoveltumor

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中文摘要
翻译
这个合作团队由来自NCI、CBC/Next、U Penn、Vanderbilt、UAB、UNM和NCATS的小组组成，旨在通过发现用于抗癌适应症的LDHA的新型抑制剂，在先前研究的基础上再接再厉。在此期间，NCATS小组作为LDHA协作团队的一部分，致力于表征新型LDH抑制剂的作用机制，指导体内疗效模型的开发，评估新型LDH降解物的体外活性，并评估新型肿瘤浓缩LDH抑制剂的体外活性。多份出版物正在筹备中，技术正在就与一家小型生物技术公司的外包许可进行谈判。
英文摘要
This collaborative team - composed of groups from NCI, CBC/NExT, U Penn, Vanderbilt, UAB, UNM and NCATS - aims to build on previous research by uncovering novel inhibitors of LDHA for anticancer indications. During this period, the NCATS group, as part of the LDHA collaborative team, has worked to characterize the mechanism of action of the novel LDH inhibitors, guide in vivo efficacy model development, assess in vitro activity of novel LDH degraders, and assess in vitro activity of novel tumor concentrating LDH inhibitors. Multiple publications are under preparation and technology is under negotiation for out-licensing with a small biotech.
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