Changing lives, changing brains: How modern family and work life influences ADRD risks

阿尔茨海默氏病和相关痴呆症（ADRD）的患病率预计将在2010年增加两倍。 2050.目前，尚无已知的有效治疗ADRD的方法。通过行为预防 因此，影响ADRD风险的变化至关重要，大约35%的ADRD风险是 被认为是可归因于潜在的可变因素。现代家庭生活的变化 工作和家庭结构可能对ADRD的风险有重要影响， 可能与ADRD风险相关的个人生活和环境的多个方面。 然而，工作和家庭轨迹作为ADRD风险的途径和调节剂的研究不足。 我们的总体假设是，当代家庭模式和工作生活的变化有助于 与年龄相关的认知变化和ADRD。转向“现代”家庭结构和工作 在挪威，这些任务的完成相对较早，而且独特的数据可用性允许这些变化 进行前瞻性研究，以预测美国和其他国家ADRD的未来变化。 我们将研究生活过程中的影响和家庭和工作之间的相互作用，在成年的风险 老年人的ADRD和认知障碍。这将通过利用异常 挪威HUNT（Nord-Trondelag健康研究）数据集，一个正在进行的大型前瞻性人群 包括1900 - 1960年出生的队列，结合挪威国家登记数据。使用 这些具有人口代表性的队列具有非常详细的健康和社会经济状况， 纵向数据来解决这些问题。我们将利用特定的事件， 自然实验我们的研究结果将有助于确定生命过程中的“敏感期”， 它们如何介导认知能力下降和ADRD的遗传风险。

The prevalence of Alzheimer's disease and related dementias (ADRD) is projected to triple by 2050. Currently, there is no known effective treatment for ADRD. Prevention through behavioral changes affecting ADRD risk is therefore of utmost importance, and about 35% of ADRD risk is thought to be attributable to potentially modifiable factors. Current changes in modern family life and work are likely to have important effects on the risk of ADRD, as the work and family structure multiple aspects of individuals lives and environments that are likely to be related to ADRD risks. Yet, work and family trajectories as pathways and moderators of ADRD risk are understudied. Our overall hypothesis is that contemporary changes in family patterns and work lives contribute to age related changes in cognition and ADRD. A shift to “modern” family structures and work tasks have occurred relatively early in Norway, and unique data availability allows these changes to be studied prospectively to predict coming changes in ADRD in the US and other countries. We will study life-course effects of and interactions between family and work in adulthood for risk of ADRD and cognitive impairment in older adults. This will be done by exploiting the exceptional Norwegian HUNT (Nord-Trondelag Health Study) dataset, a large ongoing prospective population that includes cohorts born 1900 – 1960, combined with Norwegian national registry data. Using these population-representative cohorts have exceptionally detailed health and socioeconomic longitudinal data to address these issues. We will take advantage of specific events that create natural experiments. Our results will help to identify “sensitive periods” over the life course and how they mediate genetic risks of cognitive decline and ADRD.