Clinical Laboratory Core

摘要 物质使用与慢性疾病的风险增加、进展和负面后果有关 疾病。尽管物质使用障碍(SOD)和慢性病之间的联系很好 人们对这些联系背后的具体机制缺乏了解，也没有得到充分的认识。 使用安慰剂对照、随机设计的实验研究对于理解 肥皂泡和慢性疾病之间的生理机制。该中心的研究和试点项目 布朗大学的Cobre将对成瘾和疾病风险加剧(Cadre)进行调查 阿片类药物、大麻、烟草和酒精对癌症风险影响的生理机制 SUD相关疾病的进展。在最初的四个干部研究项目中要研究的机制 包括全身炎症、免疫系统失调、高血压、肺部影响和 接触致癌物质。该干部的临床实验室核心(CLC)将为当前和未来的干部提供 研究和试点项目的调查人员具有空间、用品、设备、技术能力、科学 满足其项目需求所需的专业知识和数据管理/分析专业知识。这些 布朗没有其他可用的资源，这些资源对于实现 干部工程。通过《中图法》提供这些资源将提高效率、一致性和经济性 跨项目扩展。《中图法》核心的具体目标1是提供必要的资源来开发和 维持一个专注于肥皂水和慢性病的多学科中心。具体目标2是促进和 通过邻近的科布雷协调为干部调查人员提供的化验和其他服务。 具体目标3，一个探索性目标，是建立一个中心范围的生物库和生物，行为和数据库 与肥胖症和慢性病的发展和进展有关的环境风险因素。 《中图法》提供的资源将在现有资源的基础上发展和补充，而不是重叠。 布朗。成功实现这些目标将是一个主题和技术联系在一起的中心 支持初期和未来项目，增强项目负责人的独立竞争力 外部资金，成为了解肥皂水和肥胖症之间联系的生物行为机制的国家领导者 慢性疾病，并作为布朗内部、地区和国家培训和研究的资源。

Abstract Substance use is associated with increased risk of, progression to, and negative outcomes from chronic disease. Although associations between substance use disorders (SUDs) and chronic disease are well documented, specific mechanisms underlying these associations are poorly understood and underappreciated. Experimental studies that use placebo-controlled, randomized designs are essential for understanding physiological mechanisms that link SUDs and chronic disease. The research and pilot projects in the Center for Addiction and Disease Risk Exacerbation (CADRE) COBRE at Brown University will investigate physiological mechanisms underlying the effects of opioids, cannabis, tobacco, and alcohol on risks for and progression of SUD-related disease. Mechanisms to be studied in the initial four CADRE research projects include systemic inflammation, immune system dysregulation, high blood pressure, pulmonary effects and carcinogen exposure. The CADRE's Clinical Laboratory Core (CLC) will provide the current and future CADRE research and pilot project investigators with the space, supplies, equipment, technical capability, scientific expertise and data management/analysis expertise necessary to meet the needs of their projects. These resources are not otherwise available at Brown, and are essential for achieving the Specific Aims of the CADRE projects. Provision of these resources via the CLC will improve efficiency, consistency and economy of scale across projects. Specific Aim 1 of the CLC Core is to provide resources necessary for developing and sustaining a multi-disciplinary center focused on SUDs and chronic disease. Specific Aim 2 is to facilitate and coordinate assay and other services provided to the CADRE investigators through neighboring COBREs. Specific Aim 3, an exploratory aim, is to build a center-wide biobank and database of biological, behavioral and environmental risk factors associated with the development and progression of SUDs and chronic disease. Resources provided by the CLC will build on and complement, but not overlap, resources currently available at Brown. The successful achievement of these aims will be a thematically- and technically-linked center that supports the initial and future projects, enhances the competitiveness of the project leaders for independent external funding, becomes a national leader in understanding biobehavioral mechanisms linking SUDs and chronic disease, and serves as a resource for training and research within Brown, regionally, and nationally.