NCI Program for Natural Products Discovery - Cures

该方案的头两年包括采取必要的步骤来建立该方案。也就是说，建立基础设施，以实现提取库的自动提取、预分馏和初步纯化。这包括：翻新实验室空间，购买设备以扩大生产规模，并将其投入使用，创建标准操作程序，以及招聘和培训员工。此外，正在开发一个生物信息学平台，其中将包括一个内部数据库和面向公众的工具。在过去的一年里，该计划的公开宣布，描述该计划的三篇重要手稿的出版，预分馏方法，活性天然产物的二次提纯，以及天然产物库的装箱和筛选。此外，我们现在已经向研究界发布了第一批326,000个NP部分。在本财年，250万份碎片被运往各个筛查实验室。此外，还获得了IBC和美国农业部的批准，允许微生物提取物生产设施开始工作。此外，从澳大利亚进口了4500个海洋无脊椎动物样本和6700个海洋微生物样本。

The first two years of this program involved taking the necessary steps to establish this program. That is, putting the infrastructure in place to enable the automated extraction, pre-fractionation and initial purification of the extract library. This included: renovating laboratory space, purchasing equipment to scale up production and getting it online and creating standard operating procedures as well as hiring and training staff. In addition, a bioinformatics platform is being developed which will include an internal database and public-facing tools. This past year has seen the public announcement of the program, the publication of three significant manuscripts describing the program, the pre fractionation methodology, the secondary purification of active natural products and the crating and screening of natural product libraries. In addition we have now released the first 326,000 NP fractions to the research community. In this fiscal year, 2,500,000 fractions have been shipped to various screening laboratories. In addition IBC and USDA approvals were obtained to allow the microbial extract production facility to begin work. In addition 4500 marine invertebrate samples and 6700 marine microbe samples were imported from Australia.