Vascular Biology Section

癌症和炎症计划（CIP）的血管生物学部分旨在阐明控制血管形成和血管稳态的机制。健康的血管系统对我们的生存至关重要。它将氧气和营养物质输送到身体的每一个组织，同时清除废物并允许免疫监视。毫不奇怪，血管功能障碍与从癌症到心力衰竭的各种疾病有关。血管网的形成是为了满足发育过程中组织生长的代谢需求。当我们成年时，血管内皮细胞变得静止。然而，在疾病条件下，这种微妙的平衡被扰乱，内皮被重新激活。疾病中生理性血管生成与病理性血管生成的区别是一个重要的问题。它对治疗干预具有重要意义。我们认为炎症触发病理性血管生成，并区分病理性和生理性血管生成。该项目已于2020财年完成。

The Vascular Biology Section of the Cancer and Inflammation Program (CIP) seeks to elucidate the mechanisms that govern blood vessel formation and vascular homeostasis. A healthy vasculature is crucial to our survival. It delivers oxygen and nutrients to every tissue in the body, and at the same time removes waste and allows immune surveillance. Not surprisingly, vascular dysfunction is linked to diverse disorders, from cancer to heart failure. Vascular networks form to satisfy the metabolic demands of tissue growth during development. When we reach adulthood, the vascular endothelium becomes quiescent. However, under disease conditions, this delicate balance is disturbed and endothelium is reactivated. What distinguishes physiological from pathological angiogenesis in diseases is an important question. It has significant implications for therapeutic interventions. We propose that inflammation triggers pathological angiogenesis and distinguishes pathological from physiological angiogenesis. This project was completed in FY20.