T-cell receptor gene therapy for cancer

我们已经确定了靶向肿瘤抗原的TCRs的基因序列。我们正在测试表达这些TCR的基因工程T细胞，用于癌症患者的治疗。我们的研究重点是了解对这些治疗的反应和耐药性，目的是利用这些知识开发更有效的治疗方法。这项工作包括发现识别反应的生物标记物、提高治疗性T细胞的疗效和靶向新的肿瘤抗原的技术。

We have identified the genetic sequences of TCRs that target tumor antigens. We are testing genetically engineered T cells that express these TCRs for the treatment of patients with cancer. Our research is focused and on understanding response and resistance to these treatments with the goal to use this knowledge to develop more effective treatments. This work includes the discovery of technologies to identify biomarkers of response, enhance the efficacy of therapeutic T cells, and target new tumor antigens.