Development of a Just-in-Time Adaptive Intervention to Reduce High-Intensity Drinking among Young Adults

项目摘要/摘要 高强度饮酒(HID；女性/男性8+/10+饮料)是一种独特的过度饮酒形式 造成严重的、甚至危及生命的生理和心理后果。15%的年轻人 在过去的两周里，成年人都进行了HID，这种形式的饮酒最常发生在社交场合 设置。饮酒环境的特征(例如，酒精供应情况、活动的人口构成) 与饮酒水平有关；然而，目前对年轻人饮酒的干预 滥用不能解决饮酒环境中的实时风险因素。建议的指导性研究 科学家职业发展奖(K01)将为考克斯博士提供培训和指导，使其成为 独立的行为科学家专注于预防青少年酗酒。该计划的目标是 拟议的研究是确定年轻人HID的直接饮酒背景下的危险因素，并 使用此信息开发和试点测试即时自适应干预(JITAI)，以解决 确定了减少HID和相关后果的风险因素。为了实现她的长期职业目标，她说。 考克斯需要额外的培训。这个K01将为考克斯博士提供必要的支持，以实现以下目标 科学的培训目标：(1)获得设计移动健康干预方法的技能，(2)执行 试验设计以测试青少年酒精滥用的干预措施，(3)优先熟练掌握 为干预策略选择行为改变技术，以及(4)丰富统计能力 密集的纵向数据分析。这些目标将通过一项全面的培训计划来实现 包括一对一会议、教学/培训、导师指导的阅读材料、研讨会/实验室会议、 科学会议和实践研究经验。为了支持这些目标，考克斯博士有一个指导团队 由所有这些领域的领先研究人员组成，每个领域都有成功的NIH资助的记录 研究和丰富的指导经验。通过培训计划获得的技能将付诸实施 通过执行补充性研究计划。目标1确定吉台决策点的方式 通过一项为期4周的研究，确定饮酒环境中与HID唯一相关的因素 对50名青壮年(18-24岁)进行生态瞬时评估。目标2是迭代开发一个JITAI 这解决了已确定的风险因素，以防止在这一人群中发生HID。目标3是对吉泰进行试点测试，以达到 评估其可行性和可接受性，并b)探讨HID的初步效果。这项研究是一致的 根据NIAAA的倡议，制定有效的预防战略，以应对 过度饮酒或其他形式的酒精滥用所致。拟议中的研究将为Dr。 考克斯的第一份R01提案，将在本拟议奖项的最后一年提交。

PROJECT SUMMARY/ABSTRACT High-intensity drinking (HID; 8+/10+ drinks for females/males) is a distinct form of excessive alcohol use that results in significant, even life-threatening, physical and psychological consequences. Fifteen percent of young adults have engaged in HID in the past two weeks, and this form of drinking most often occurs in social settings. Characteristics of the drinking context (e.g. alcohol availability, demographic composition of the event) are associated with levels of alcohol consumption; however, current interventions for young adult alcohol misuse do not address real-time risk factors in the drinking context. The proposed Mentored Research Scientist Career Development Award (K01) will provide Dr. Cox with the training and mentorship to become an independent behavioral scientist focused on the prevention of young adult alcohol misuse. The objective of the proposed research is to identify risk factors in the immediate drinking context for HID among young adults and use this information to develop and pilot test a just-in-time adaptive intervention (JITAI) that addresses the identified risk factors to reduce HID and associated consequences. To achieve her long-term career goals, Dr. Cox requires additional training. This K01 will provide the necessary support for Dr. Cox to pursue the following scientific training objectives: (1) obtain skills in the design of mHealth intervention approaches, (2) execute experimental designs to test interventions for young adult alcohol misuse, (3) gain proficiency in priority selection of behavior change techniques for intervention strategies, and (4) enrich statistical capacities in the analysis of intensive longitudinal data. These objectives will be met through a comprehensive training plan that consists of one-on-one meetings, didactics/trainings, mentor-directed readings, seminars/lab meetings, scientific meetings, and hands-on research experience. To support these goals, Dr. Cox has a mentoring team comprised of leading researchers in all of these areas that each have a record of successful NIH-funded research and extensive mentoring experience. Skills gained through the training plan will be put into action through the execution of the complementary research plan. Aim 1 is to determine JITAI decision points by identifying factors in the drinking context that are uniquely associated with HID via a 4-week study using ecological momentary assessment with 50 young adults (ages 18-24). Aim 2 is to iteratively develop a JITAI that addresses identified risk factors to prevent HID among this population. Aim 3 is to pilot test the JITAI to a) assess its feasibility and acceptability, and b) explore preliminary effects on HID. This research is consistent with NIAAA’s initiative to develop effective prevention strategies that address the risks for consequences that result from excessive drinking or other forms of alcohol misuse. The proposed study will provide data for Dr. Cox’s first R01 proposal, to be submitted in the final year of this proposed award.