BLR&D Research Career Scientist Award Application

项目总结 范杰，M.D.，M.Sc.此后一直在退伍军人事务部匹兹堡医疗系统(VAPHS)工作 2003年，他是多学科外科研究计划的主任， VAPHS机构生物安全委员会，外科系终身正教授 在匹兹堡大学。他是研究细胞和分子的首席研究员 脓毒症、创伤后全身炎症反应综合征(SIRS)和急性肺的发病机制 损伤(ALI)，这是一个重要但异常困难的领域。他的实验室得到了两名退伍军人管理局的资助 功绩审查补助金和四项NIH研究补助金(R01、P50和R56)。 与创伤相关的疾病的负担是相当大的。在失血和/或脑出血后 通常会导致早期死亡的损伤，60%以上的存活患者后来死于 与SIRS、脓毒症和ALI的发生有关的原因。这个病人群体非常适合 预防干预旨在防止这些事件的发生，因为在 出现器官炎症和衰竭。尽管如此，几乎没有明确的目标是 倾向于SIRS和ALI。范博士研究的长期目标是提供一种新的理解 创伤后炎症和器官功能障碍的机制，因此，可能 为创伤后全身炎症反应综合征、败血症和ALI的预防和治疗干预提供新的靶点。 范博士团队的研究也将提供对多发性硬化症发病机制的更多了解 炎症在其中起核心作用的人类疾病。 ALI是全身炎症反应综合征和脓毒症的共同终点之一。全身炎症反应综合征和脓毒症是引起 退伍军人手术、感染、脊柱损伤、中风、出血和创伤后的死亡率 人口。因此，范博士的研究与退伍军人的健康高度相关。 范博士的研究提供了关键信息，可用于开发 为患有创伤后炎症和ALI的退伍军人提供治疗。他是一个工作效率很高的校长 在退伍军人事务部和美国国立卫生研究院的资助方面有长期记录的调查员。他还曾担任过以下角色 多项其他研究资助的联合研究员、顾问和合作者。他的研究和 合作产生了113篇同行评议的出版物，其中许多是最好的科学论文 影响因子较高的期刊，包括《自然医学》、《自然通讯》、《 临床研究，肝病学，肝病学杂志，细胞死亡与分化， 免疫学。范博士的工作在国内外同行中享有盛誉。他一直是一个 在许多国内和国际会议上以及在许多研究和 教育机构。他是多个国家同行评审委员会的评审员， 包括退伍军人事务部、美国国立卫生研究院、美国国防部和美国生物科学学会的研究部门。他还服务于 主编，编委会成员，50多种科学期刊特邀审稿人。他有 指导了27名退伍军人和非退伍军人训练生，包括博士后候选人、博士后研究员、住院医生、初级 外科学院和访问学者，他们中的许多人现在已经成为独立科学家或 内科科学家。范博士是2010年杰出政府奖的获得者 对医学科学的贡献。

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003, and is a Director of the Multidisciplinary Surgical Research Program, a Vice Chair of the Institutional Biosafety Committee in VAPHS, and a tenured Full Professor of the Department of Surgery at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of sepsis, post-trauma systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been funded by two VA merit review grants and four NIH research grants (R01, P50, and R56). The burden of trauma-related diseases is considerable. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long term goal of Dr. Fan’s studies is to provide a new understanding of the mechanisms of post-trauma inflammation and organ dysfunction, and therefore, to potentially provide novel targets for preventive and therapeutic interventions in post-trauma SIRS, sepsis, and ALI. The studies by Dr. Fan’s team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan’s research is highly relevant to Veterans’ health. Dr. Fan’s research provides critical information that can be used toward the development of therapies for veterans with post-trauma inflammation and ALI. He is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other research grants. His research and collaborations have resulted in 113 peer-reviewed publications, many of them in the best scientific journals and with high impact factors, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan’s work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a reviewer in a number of national peer-review committees, including VA, NIH, DoD, and American Institution of Biological Sciences study sections. He also serves as editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 27 VA and non-VA trainees including Ph.D. candidates, postdoctoral fellows, residents, junior surgery faculties, and visiting scholars, many of whom have now become independent scientists or physician scientists. Dr. Fan is a 2010 recipient of the Excellence in Government Award for Outstanding Contribution to Medical Sciences.