Pilot

项目摘要摘要 试点项目计划是NAMDC的重要组成部分，支持1-2个试点项目 每年一次。NAMDC试点项目侧重于生物标志物、诊断、自然病史和治疗 线粒体疾病。因此，项目必须是人体研究，包括：病人、人类 细胞、组织或体液样本。试点拨款通常是初级调查人员的第一步， 其中赠款申请通常是第一次正式申请。Pilot Core提供多个 初级调查人员的指导步骤，包括反馈：关于初步建议(包括 未获资助的改善申请质素的建议)，以及全额拨款发展 过程中，以及在项目实施过程中。指导工作由NAMDC PI、统计PI、 试点核心PI、本地站点PI、NAMDC临床联络，并根据需要提供额外资源。这个 NAMDC试点/新计划委员会负责审查试点/新项目 提案。试点项目的申请者必须是NAMDC成员。NAMDC试点项目 委员会建议作出最能满足以下方面的需要和优先事项的供资决定 并鼓励其发展。选择资助是基于以下信息： 在年度面对面会议上进行口头陈述后，来自NAMDC PIS的书面同行审查和 面对面的会议。根据试点方案委员会的建议，NAMDC 执行委员会最终决定资助哪些试点项目/新项目 在RDCRN的投入和NIH官员的批准下。多中心研究将是 优先于单一地点的研究项目。申请者为发生的项目申请资金 在NAMDC的12个月窗口期间，NIH的年度供资周期。这意味着申请者 申请在以下日期9月1日至8月31日期间进行的项目 年。受赠人应提交一份简短的季度报告、初步报告演示文稿 在年度面对面会议上，并在会议结束后两个月内提交最终报告 格兰特。

Project Summary Abstract The Pilot Project Program is an important component of NAMDC, and supports 1-2 pilot projects annually. NAMDC pilot projects focus on biomarkers, diagnosis, natural history, and treatment of mitochondrial diseases. Thus, projects must be human subject studies, including: patients, human cells, tissues, or body fluid samples. Pilot grants are often a first step for junior investigators, where the grant application is often a first formal application. The Pilot Core provides multiple mentoring steps for junior investigators including feedback: on initial proposals (including unfunded proposals to improve the quality of the application), along the full grant development process, and during project implementation. Mentoring is done by the NAMDC PI, Statistical PI, Pilot Core PI, local site PI, NAMDC Clinical Liaison, and additional resources as needed. The NAMDC Pilot/New Program Committee is responsible for reviewing the pilot/new project proposals. Applicants for Pilot Projects must be NAMDC members. The NAMDC Pilot Project Committee recommends funding decisions that best meets the needs and priorities of the consortium and encourages its growth. Selection for funding is based upon information from written peer review and from the NAMDC PIs following oral presentation at the annual Face-to- Face meeting. Following the recommendation by the Pilot Program Committee, the NAMDC Executive Committee makes the ultimate decision as to what pilot/new projects will be funded with input from the RDCRN and approval from the NIH officers. Multicenter studies will be prioritized over a single-site study projects. Applicants apply for funding for projects that occur during the 12-month window of NAMDC yearly cycle of NIH funding. This means that applicants apply for projects that will be carried out between September 1st through August 31 of the following year. Grantees are expected to submit a brief quarterly report, a preliminary report presentation at the annual Face-to-Face meeting, and a final report within two months of the conclusion of the grant.