Center for Methodologies for Adapting and Personalizing Prevention, Treatment and Recovery Services for SUD and HIV (MAPS Center)

项目概要：总体 有效的预防，治疗和物质使用障碍（SUD）和艾滋病毒的康复服务需要一个 越来越多的循证干预措施，以解决个人不断变化的优势，需求， 情节这可以通过自适应干预来实现，这些干预明确指导如何修改类型/ 基于个人信息的服务强度。此外，数字技术的进步，如 作为电子健康记录（EHR）和移动的设备， 用于使干预措施适应不同水平的数据（例如，个体、诊所、卫生系统），模态（例如， 数字的、亲自的），和/或时间尺度（例如，一个月，一天几次）。但新的研究 需要有各种方法来实现这些机会，并为新一代的可持续发展/艾滋病毒服务提供信息。 拟议的中心的重点是调整和个性化的预防，治疗， SUD和艾滋病毒恢复服务（MAPS中心）是开发和传播新的 研究方法对于优化适应性干预措施以抗击SUD/艾滋病毒至关重要。我们提出 三个令人兴奋的，主题整合的研究项目，每个开发新的方法，以经验为基础， 建立适应性的可持续发展/艾滋病毒服务。两个创新主题-优化（即，发展中 以不太昂贵、复杂或苛刻的方式实现最佳预期结果的服务， 可缩放）和自适应（即，利用有关环境和不断变化的需求的信息， 干预）-跨越这些项目，使我们的团队能够推动SUD/HIV干预科学向前发展 同时为科学协同创造了巨大的潜力。沿着三个项目，两个核心- 传播与培训核心和行政核心-将使MAPS中心成为国家级的 通过培训SUD/艾滋病毒科学家关键使用方法，招募科学家 优化适应性SUD/艾滋病毒服务，并指导早期职业学者。总的具体目标 MAPS中心是：（目的A）开发新的实验和数据分析方法，以优化 在不同级别调整可持续发展/艾滋病毒服务（例如，个体、诊所），模态（例如，亲自， 数字的），和时间尺度（例如，（目标B）作为一种国家资源， MAPS中心开发的创新方法直接交到SUD/HIV科学家手中;以及（目标C） 培养和建设科学家设计实验和分析数据的能力， 发展适应性的可持续发展/艾滋病毒服务。MAPS中心将为新一代的高度 * 采取有效和可扩展的干预措施，减少性剥削和性剥削及艾滋病毒感染的流行率和发生率。

PROJECT SUMMARY: OVERALL Effective prevention, treatment, and recovery services for substance use disorders (SUD) and HIV demand an increasing array of evidence-based interventions to address individuals' changing strengths, needs, and circumstances. This can be achieved via adaptive interventions, which explicitly guide how to modify the type/ intensity of services based on information about the individual. Further, advances in digital technologies, such as electronic health records (EHRs) and mobile devices, have created unprecedented opportunities to obtain data for use in adapting interventions to different levels (e.g., individual, clinic, health system), modalities (e.g., digital, in-person), and/or time scales (e.g., monthly, many times a day). However, new research methodologies are needed to realize these opportunities and inform a new generation of SUD/HIV services. The focus of the proposed Center for Methodologies for Adapting and Personalizing Prevention, Treatment, and Recovery Services for SUD and HIV (MAPS Center) is the development and dissemination of novel research methodologies that are essential to optimize adaptive interventions to combat SUD/HIV. We propose three exciting, thematically integrated research projects, each developing new methods to empirically inform the construction of adaptive SUD/HIV services. Two innovative themes — optimization (i.e., developing services that achieve the best expected outcome in a way that is not too expensive, complex, or demanding to be scalable) and adaptation (i.e., using information about context and changing needs to decide when and how to intervene) — cut across these projects, enabling our team to move SUD/HIV intervention science forward while creating enormous potential for scientific synergy. Along with the three projects, two cores — Dissemination & Training Core and Administrative Core — will enable the MAPS Center to serve as a national resource by training SUD/HIV scientists in the critical use of the methods, recruiting scientists to work on optimizing adaptive SUD/HIV services, and mentoring early career scholars. The overall Specific Aims of the MAPS Center are: (Aim A) To develop novel experimental and data analytic methods to optimize the adaptation of SUD/HIV services across different levels (e.g., individual, clinic), modalities (e.g., in-person, digital), and time scales (e.g., monthly, daily); (Aim B) To serve as a national resource by placing the innovative methods developed in the MAPS Center directly into the hands of SUD/HIV scientists; and (Aim C) To nurture and build capacity among scientists to design experiments and analyze data to inform the development of adaptive SUD/HIV services. The MAPS Center will pave the way for a new generation of highly effective and scalable interventions that will reduce the prevalence and incidence of SUD and HIV infection.