Bioinformatics and Biostatistics Core

项目摘要 生物统计和生物信息学核心(核心C)的目标是处理统计设计和分析 耶鲁大学头颈部癌症(YHN-SPORT)项目的需求、核心、发展 研究计划(DRP)和职业发展计划(CDP)。为了实现这一目标，我们有 组建了一个由癌症生物统计学家和生物信息学家组成的高度互动的团队，他们将 与基础、临床、翻译和人口科学研究人员协作，推动 抗癌药物。生物统计和生物信息学核心的具体目标是： 目标1​：​在设计、执行、监控和分析基本、 Yhn孢子的翻译、种群和临床研究。 目标2​：​监督和协调数据的收集、管理和分析。确保收集的数据 所有的孢子研究都是高质量的，用生物信息学和统计学的严谨性进行评估，是 可在与孢子相关的协作组中访问，最终实现最广泛的可访问性 考虑到出版和隐私方面的问题，这是适当的。 对于目标1，核心将与研究人员密切合作，分析临床试验和临床前数据，NEXT 世代测序数据和生物信息学数据挖掘。核心所提供的服务范围包括 规划和设计活动，就特定的分析问题提供咨询。核心将针对分析 以及YHN-SPORT项目产生的信息学问题。核心将严格设计和监控 安全性、有效性和无效性的临床试验。核心将安排定期与YHN-Spop举行会议 调查人员，并对任何生物统计学和生物信息学问题保持开放政策。《核心》 将进行中期和最终分析，根据需要开发新的统计和生物信息学方法， 为孢子研究人员提供及时的建议，从而在整个研究中发挥重要作用。 生物统计和生物信息学也是YHN孢子的关键合作伙伴，在他们的高级代表中有代表 领导团队并参与所有核心会议。对于Aim 2，核心将与耶鲁癌症合作 耶鲁大学分析科学中心(YCAS)、福克斯·蔡斯癌症中心(Fccc)及其 促进YHN孢子研究人员之间沟通的量化核心，创建和实施 用于收集、存储和访问各种类型数据的网络可访问数据库(例如， 临床、种群和基因组数据)，这些数据将为YHN-SPORT项目生成。核心是高度 与项目相结合，并将与项目调查人员以及YCAS数据定期举行会议 管理人员，评估研究产生的数据，并确保准确和最新的数据 管理层。 ​​ ​​

Project Summary The goal of the Biostatistics and Bioinformatics Core (Core C) is to address the statistical design and analysis needs of the Yale SPORE in Head and Neck Cancer (YHN-SPORE) Projects, the Cores, the Developmental Research Program (DRP), and the Career Development Program (CDP). To accomplish this goal we have assembled a highly interactive team of cancer biostatisticians and bioinformaticians who will work collaboratively with basic, clinical, translational, and population science researchers to advance the frontiers of cancer medicine. The specific aims of the Biostatistics and Bioinformatics Core are: Aim 1​: ​Provide collaboration and consulting in the design, execution, monitoring and analysis of basic, translational, population, and clinical studies for YHN-SPORE. Aim 2​: ​Oversee and coordinate the collection, management, and analysis of data. Ensure that data collected on all YHN-SPORE studies are of high quality, are evaluated with bioinformatic and statistical rigor, are accessible within SPORE-affiliated collaborative groups, ultimately enabling the widest accessibility that is appropriate given publication and privacy concerns. For Aim 1, the Core will work closely with the investigators to analyze clinical trial and pre-clinical data, next generation sequencing data, and bioinformatics data mining. Services provided by the Core will range from planning and design activities to consulting on specific analytic questions. The Core will address the analytic and informatics questions arising from the YHN-SPORE projects. The Core will rigorously design and monitor clinical trials for safety, efficacy and futility. The Core will schedule regular meetings with the YHN-SPORE investigators, and maintain an open-door policy for any biostatistical and bioinformatics questions. The Core will conduct interim and final analyses, develop new statistical and bioinformatics methodology as needed, provide timely suggestions to YHN-SPORE investigators, and thus play an important role in the entire study. Biostatistics and Bioinformatics is also a key partner in the YHN-SPORE with representation on their Senior Leadership Team and participation in all core meetings. For Aim 2, The Core will work with the Yale Cancer Center (YCC), Yale Center for Analytical Sciences (YCAS), Fox Chase Cancer Center (FCCC) and its quantitative cores to facilitate communication among YHN-SPORE researchers, creating and implementing web-accessible databases for collecting, storing and accessing the various types of data (e.g. laboratory, clinical, population, and genomic data) that will be generated for the YHN-SPORE projects. The Core is highly integrated with the projects, and will have regular meetings with project investigators, as well as YCAS data managers, to evaluate the data generated from the studies and ensure accurate and up-to-date data management. ​​ ​​