Regional Centre for Vector Borne Diseases in West Africa (RCVBD)

项目总结 尽管西非目前疟疾的发病率达到了前所未有的高水平，但这项研究 非洲的能力太低，无法实现疟疾控制和消除的目标。此外，许多新的 发达国家开发的技术和工具没有被非洲很好地利用 科学家。例如，分子种群遗传学、基因组学和生物信息学的新工具以及 在非洲，疾病建模尚未纳入疟疾研究和控制。低研究 与其他非洲地区相比，西非的产能要糟糕得多。因此，有一个 迫切需要加强西非传染病的研究能力。我们建议 该西非媒介传播疾病区域中心(RCVBD)将提高研究能力 通过培训博士生和初级教员以及 研究科学家。该财团的合作伙伴来自西非的三个机构( 加纳、冈比亚医学研究理事会股和德拉科学研究所 布基纳法索的Santé)。来自三个美国机构的合作者(加州大学欧文分校， 新墨西哥大学和西北大学)将协助培训计划。整体而言 该培训计划的目标是通过培训下一个 在媒介传播疾病研究和控制领域的一代非洲科学家 特别关注疟疾。培训的主题领域包括流行病学、医学昆虫学 以及新的遗传、基因组和生态研究工具的应用。我们提出了三条途径： 训练。第一条轨道是在西非对8名博士生进行长期培训。轨道2将提供短路- 年对卫生部15名初级大学教职员工和初级科学家进行了学期研究培训 在西非开展疟疾研究和控制所需的具体技能培训。轨道3将是培训 向相关社区广泛传播技术和知识的讲习班和短期课程 在西非的媒介传播疾病研究和控制方面。本培训计划将重点放在四个方面 迫切需要的科学领域，包括1)疟疾流行病学和昆虫学的新工具 监测，2)抗疟疾药物对青蒿素和伙伴药物的耐药性，3)群体基因组学 4)建立疟疾传播动力学模型和疟疾干预模型 战略。这一研究培训计划将通过以下方式帮助推进西非科学家的职业生涯 通过积极的导师和杰出的 出版物，用新的知识和技能武装他们，并加强他们的协作 非洲内外科学家的机会。

PROJECT SUMMARY Although West Africa is currently burdened with an unprecedented high levels of malaria, the research capacity in Africa is too low to meet the malaria control and elimination goal. Furthermore, many new techniques and tools developed in the developed countries have not been well utilized by Africa scientists. For example, new tools in molecular population genetics, genomics and bioinformatics and disease modeling have not been integrated into malaria research and control in Africa. Low research capacity in West Africa is far more dire in comparison to other African regions. Therefore, there is an immediate need to strengthen the research capacity in infectious diseases in West Africa. We propose this Regional Centre for Vector Borne Diseases in West Africa (RCVBD) to enhance research capacity in malaria epidemiology and medical entomology through training PhD students and junior faculty and research scientists. The consortium partners are from three West African institutions (University of Ghana, The Medical Research Council Unit Gambia, and Institut de Recherche en Sciences de la Santé of Burkina Faso). Collaborators from three US institutions (University of California at Irvine, University of New Mexico and the Northwestern University) will assist the training program. The overall goal of this training program is to enhance research capacity in West Africa by training the next generation of African scientists in the area of vector-borne disease research and control with a special focus on malaria. The thematic areas of training include epidemiology, medical entomology and application of new genetic, genomic and ecological research tools. We propose three tracks of training. Track 1 will be long-term training of 8 PhD students in West Africa. Track 2 will provide short- term research training to 15 junior university faculty and junior scientists from the Ministry of Health in West Africa to foster specific skills required for malaria research and control. Track 3 will be training workshops and short courses to disseminate techniques and knowledge to wide communities involved in vector borne disease research and control in West Africa. This training program will focus on four scientific areas in urgent need, including 1) new tools for malaria epidemiological and entomological surveillance, 2) antimalarial drug resistance to artemisinin and partner drugs, 3) population genomics of insecticide resistance, and 4) modeling malaria transmission dynamics and malaria intervention strategies. This research training program will help advance the careers of West African scientists by strengthening their academics and research productivity through vigorous mentorship and outstanding publications, equipping them with new knowledge and skills, and enhancing their collaborative opportunities with scientists within and out of Africa.