Cancer Epigenetics Training Grant

项目摘要 该提案寻求支持6名博士后研究员的培训计划，重点是癌症表观遗传学， 癌症研究的一个关键领域。这一领域的培训需求稳步增加，突出了 需要强有力的培训计划。令人惊讶的是，目前还没有国家癌症研究所资助的培训项目关注这一主题。 存在.北卡罗来纳大学教堂山分校最近成为表观遗传学和癌症研究的“中心”， 教师谁积极进行表观遗传学为重点的研究。因此，我们建议创造第一个巨蟹座 表观遗传学培训计划（CETP），利用我们在染色质和癌症生物学领域的专业知识， 大学和Lineberger综合癌症中心（LCCC）的资源。这一池 导师将允许研究员从事跨学科的研究，在癌症的亚专业 表观遗传学：组蛋白生物学，DNA甲基化，染色质重塑，RNA和化学生物学。的CETP 该计划将由一名主任和副主任管理，并听取培训监督的建议 委员会和外部和内部咨询委员会。项目评估还将包括导师和 学员通过年度匿名调查的意见。获得LCCC的核心设施，由NCI核心支持 赠款（评级为“特殊”）将进一步改善培训环境。LCCC还将提供重要的 通过资助培训活动、EAB年度访问、面谈和受训人员的差旅费和住宿费提供支助 参加科学会议的差旅费以及项目主任和工作人员的工资支持。 研究员将联合申请CETP和一个或多个导师实验室，并进行严格的筛选 过程在任命时，每个研究员将制定一个培训计划，由导师，主任， 和副主任，并建立一个指导委员会。在CETP的前两年，每个研究员 将参加以下培训活动：（一）CETP座谈会，涵盖表观遗传学的广度， 癌症发展和治疗的背景下，（ii）每年CETP研讨会，目前的研究项目， (iii)研究伦理培训（四）每月研究俱乐部，以及（五）赠款撰写和赠款审查方案。 研究员还可根据个人培训计划参加赞助的相关培训活动 的LCCC。主任和副主任将每年监测进展情况，沿着培训， 监督委员会，在续签第2年支持之前。虽然研究员得到两年的支持，我们的 学员将积极参与CETP计划，并在其任职期间参加多个活动。 CETP将通过与历史上的黑人和少数民族的联系，从代表性不足的少数民族中招募学员。 西班牙裔大学和我们关于癌症表观遗传学的年度研讨会。完成CETP的学员 将成为独立的研究人员，专注于癌症研究的这一重要新领域。

PROJECT SUMMARY This proposal seeks support for 6 postdoctoral fellows for a training program focused upon cancer epigenetics, a critical area of cancer research. Demand for training in this area has steadily increased, highlighting the crucial need for robust training programs. Surprisingly, no NCI-funded training program focused on this topic currently exists. UNC-Chapel Hill has recently emerged as a “hub” for epigenetics and cancer research, with over 35 faculty who actively perform epigenetics-focused research. Thus, we propose to create the first Cancer Epigenetics Training Program (CETP), leveraging our expertise in the area of chromatin and cancer biology with the resources of the University and the Lineberger Comprehensive Cancer Center (LCCC). This pool of preceptors will allow fellows to engage in interdisciplinary studies across the subspecialties of cancer epigenetics: Histone Biology, DNA Methylation, Chromatin Remodeling, RNA and Chemical Biology. The CETP program will be administered by a Director and Associate Director, with advice from a Training Oversight Committee and External and Internal Advisory Boards. Program evaluation will also include preceptor and trainee input via an annual, anonymous survey. Access to the LCCC’s core facilities, supported by the NCI Core Grant (rated “exceptional”), will further enhance the training environment. The LCCC will also provide significant support by funding of training events, yearly EAB visits, travel and lodging costs for interviews and for trainee travel to scientific meetings and salary support for program directors and staff. Fellows will jointly apply to the CETP and one or more mentor laboratories and undergo a rigorous selection process. Upon appointment, each fellow will develop a training plan approved by the preceptor, the Director, and Associate Director and establish a mentorship committee. During their first 2 years in the CETP, each fellow will participate in the following training events: (i) CETP colloquia that cover the breadth of epigenetics in the context of cancer development and treatment, (ii) a yearly CETP symposium to present current research projects, (iii) training in ethics in research (iv) a monthly research club, and (v) a grant writing and grant review program. Based on their individualized training plans, fellows may also participate in relevant training events sponsored by the LCCC. Progress will be monitored annually by the Director and Associate Director, along with the Training Oversight Committee, before renewal for Year 2 support. Although fellows are supported for two years, our trainees will be active in the CETP program and participate in multiple events throughout their tenure at UNC. The CETP will recruit trainees from underrepresented minorities through outreach to historically black and Hispanic universities and our yearly symposium on cancer epigenetics. The trainees who complete the CETP will be poised to become independent investigators focused upon this vital new area of cancer research.