Brain Banking Core

脑库核心 摘要 尽管我们在加深对创伤性脑损伤(TBI)的认识方面取得了很大的进展 相关的神经退行性变(趋势)，我们还没有到合适的治疗方法是 可用。这在一定程度上是由于可用于研究的合适的人脑组织样本数量有限。 研究机构。事实上，只有一个人脑组织档案专门用于脑损伤样本， 位于英国苏格兰的格拉斯哥大学。为了克服这种资源匮乏，大脑 CONNECT-TBI的银行核心将汇集九家参与银行，这些银行将能够提供 现有的组织样本来自近2000个急性和800多个慢性脑损伤病例。这个大脑银行核心将 建立一个独特和全面的所有现有脑外伤相关尸检组织的中央档案，其中将包括 所有可用组织和相关临床数据的广泛清单。CONNECT-TBI专家共识 小组成员将对数字扫描的图像进行评估和评分。在这个大脑中，银行核心将是高的 高质量、强大的临床数据集和数字化组织学切片，不仅将支持研究项目 在这项建议内，但得到批准的支持，外部，研究人员领导的研究。此外，英国广播公司将 建立来自所有参与中心的组织捐赠网络，这将显著增加 可获得的组织样本。在所有努力中，Brain Banking核心将优化最佳实践协议并将 确保遵守严格的组织处理、染色和扫描方案。最后，脑库核心将 促进传播所有与TBI有关的样本和数据，以支持以下研究项目 构成了CONNECT-TBI的使命。

BRAIN BANK CORE SUMMARY Although we have made great progress in gaining a deeper understanding of traumatic brain injury (TBI) related neurodegeneration (TReND), we have not gotten to the point where appropriate thereapeutics are available. This is, in part, due to the limited number of suitable human brain tissue samples available to research institutions. In fact, there exists only one human brain tissue archive dedicated to TBI samples, located at the University of Glasgow in Scotland, UK. In order to overcome this lack of resource, the Brain Banking Core of CONNECT-TBI will bring together nine participating banks that will be capable of providing existing tissue samples from almost 2000 acute and over 800 chronic TBI cases. This Brain Banking Core will establish a unique and comprehensive central archive of all existing TBI related autopsy tissue, that will include a broad inventory of all available tissue and associated clinical data. The CONNECT-TBI Expert Consensus Group members will assess and score digitally scanned images. Within this Brain Banking Core will be high quality, robust clinical datasets and digitized histology sections that will not only support the Research Projects within this proposal, but support approved, external, researcher led studies. Furthermore, the BBC will establish a tissue donation network from all participating centers that will significantly enhance the number of available tissue samples. In all efforts, the Brain Banking Core will optimize best practice protocols and will ensure adherence to strict tissue handling, staining, and scanning protocols. Finally, the Brain Bank Core will facilitate the dissemination all TBI-related samples and data in support of the Research Projects which comprise the mission of CONNECT-TBI.