NIA Interlab: Targeting the Mechanism in Type 2 Diabetes

维尔纳综合征是一种以头发变白、脱发、白内障、身材矮小、皮肤溃疡、2型糖尿病、心肌梗死、动脉粥样硬化和恶性肿瘤为特征的早衰疾病。超过一半的维尔纳综合征患者患有糖尿病。然而，对Werner综合征相关糖尿病的机制了解有限。这种信息的缺乏使得对WS患者糖尿病的靶向治疗变得困难。在目前的项目中，我们将研究胰岛素信号在wrn缺陷小鼠、秀丽隐杆线虫和细胞系模型中的作用。我们将进行分析，以确定wrn缺乏模型系统中的代谢失调。该研究将为理解WS患者2型糖尿病的分子发病机制提供重要见解。本研究具有临床意义，在成功完成后，我们希望将提供针对WS患者糖尿病的治疗策略。

Werner syndrome is a premature aging disorder characterized by graying and loss of hair, cataracts, short stature, skin ulcers, type-2 diabetes, myocardial infarction, atherosclerosis, and malignancy. More than half of Werner syndrome patients get diabetes. However, there is limited understanding of the mechanism involved in Werner syndrome-associated diabetes. This lack of information makes it difficult to target treatment for diabetes in WS patients. In the current project, we will be investigating the role of insulin signaling in Wrn-deficient mice, C.elegans and cell line models. We will perform analyses to determine the metabolic deregulation in Wrn-deficient model systems. The proposed investigation will provide critical insight towards understanding the molecular pathogenesis associated with type-2 diabetes in WS patients. This study is of clinical relevance and upon successful completion we hope will provide therapeutic strategies to target diabetes in WS patients.