Development and Cancer Scientific Program

我们目前对人类癌症的理解强调了异常发育程序在癌症中的重要性。 癌症发病机制考虑到这一点，西蒙斯癌症中心的领导层创建了 和癌症（DC）科学计划作为其支柱之一。 计划成员继续反映努力全面达到整个校园侧翼 实验室研究人员与医生科学家。来自16个部门的34名成员包括16名 教师与正式的临床或临床科学家的培训，完全准备关闭之间的差距 长凳和床边。DC计划包括来自癌症，干细胞和肿瘤领域的研究人员。 发展生物学，利用现有的优势和最近的招聘，以解决关键问题， 这将使我们能够改善癌症的诊断，治疗，并最终预防。互补对方 在癌症中心的科学项目中，DC成员调查了发育和进化 保守的祖先主题是细胞和有机体生长，发育和生理学的基础， 以及这些因素如何影响癌症生物学。为了涵盖如此多样化的发展属性，DC领导人 确定了构成方案核心结构的五个主题： ·主题1。肿瘤-间质相互作用; ·主题2。癌基因与抑癌基因生物学; ·主题3。癌细胞程序设计; ·主题4。表观遗传学和细胞命运;以及 主题5。干细胞生物学 目前的NCI（410万美元）和同行评审资金总额（2490万美元）几乎是赠款资金的两倍 在2009年项目启动时。重要的是，几个资助的项目代表了多个研究者的努力， 超越我们的制度。DC计划成员自2010年以来已经撰写了327篇同行评审的出版物。 在最近一次审查之前的三年里，生产率几乎翻了一番。的 具有项目内（13%）和项目间（36%）足迹的手稿也几乎翻了一番， 其中24%包括来自其他NCI指定癌症中心的研究人员。

Our current understanding of human cancer highlights the importance of aberrant developmental programs in cancer pathogenesis. With this in mind, leadership of the Simmons Cancer Center created the Development and Cancer (DC) Scientific Program as one of its pillars. Program membership continues to reflect efforts to comprehensively reach across the campus by flanking laboratory researchers with physician-scientists. The 34 members drawn from 16 departments include 16 faculty members with formal clinical or clinician-scientist training, perfectly poised to close the gap between the bench and bedside. The DC Program includes investigators from the fields of cancer, stem cell, and developmental biology, exploiting existing strengths and recent recruitments, to tackle the crucial questions that will allow us to improve cancer diagnosis, therapy, and ultimately, prevention. Complementing the other scientific programs in the Cancer Center, DC members investigate the developmentally and evolutionarily conserved ancestral themes that are fundamental to cell and organism growth, development, and physiology, and how these factors influence cancer biology. To cover such diverse developmental properties, DC leaders identified five themes that form the core structure of the program: • Theme 1. Tumor-Stroma Interactions; • Theme 2. Oncogene and Tumor Suppressor Gene Biology; • Theme 3. Cancer Cell Programming; • Theme 4. Epigenetics and Cell Fate; and • Theme 5. Stem Cell Biology. The current NCI ($4.1 million) and total peer-reviewed funding ($24.9 million) nearly doubles the grant funding at the program’s inception in 2009. Critically, several funded projects represent multi-investigator efforts within and beyond our institution. DC Program members have authored 327 peer-reviewed publications since the past review, nearly doubling the productivity for the three years prior to the most recent review. The manuscripts with intra-programmatic (13%) and inter-programmatic (36%) footprints nearly doubled as well, and 24% of them included investigators from other NCI-designated cancer centers.