Georgia Cystic Fibrosis Research and Translation Core Center

项目摘要--行政核心 本申请建议建立佐治亚州囊性纤维化研究和翻译核心中心，地址为 埃默里大学、奥古斯塔大学和佐治亚理工学院(以下称为“佐治亚州CF核心 中心“)，它将利用这三个机构的广泛活动来解决相关问题 患有这种慢性的系统性疾病。由佐治亚州CF核心中心支持的研究将集中在以下方面 对于NIDDK的使命至关重要的CF疾病，包括CF相关糖尿病(CFRD)，CF对 营养状况、胃肠功能、肝功能(包括慢性萎缩性肝病)，以及 新陈代谢，以及这些并发症与生活方式/行为选择的关系 比如饮食、锻炼、活动和睡眠。由佐治亚州CF核心中心主任Nael McCarty博士领导， 管理核心将三个主要机构联系在一起，追求产生新的研究成果 对慢性阻塞性肺疾病临床护理有影响的知识。行政核心负责整体 领导、协调和管理佐治亚州CF核心中心，包括促进互动 在调查人员和核心用户中，分配和监督资源，并促进该中心。这个 管理核心还将通过以下方式满足中心成员和CF患者/家庭社区的需求 提供高质量的丰富和传播计划，将扩展到所有三个主要 机构。我们将通过以下具体目标和活动实现这些目标： 目标1.制定和实施一项战略计划，以形成、扩大和优化 埃默里大学、佐治亚理工学院和奥古斯塔大学以及其他地区性机构。理由：经过深思熟虑的 而执行的战略计划对于有效促进和传播CF研究是至关重要的。 目标2.为所有CF研究项目提供监督和指导、监控进度并促进增长 和核心。基本原理：实施协同、协调和集成的计划，以推进CF 研究需要高级别的行政指导和监督。该中心的有效性取决于 它有能力明智地使用资源，实现其目标，并在必要时将中心的目标调整为研究 问题、挑战、机遇和支持需求不断演变。 目标3.促进核心中心机构和调查人员之间的互动和沟通。 基本原理：实现跨学科互动、协作和有效沟通促进 凝聚力、创造力和生产力。

PROJECT SUMMARY – Administrative Core This application proposes to establish the Georgia Cystic Fibrosis Research and Translation Core Center at Emory University, Augusta University, and Georgia Tech (hereafter referred to as the “Georgia CF Core Center”), which will leverage a wide range of activities at these three institutions to solve problems associated with this chronic, systemic disease. Research supported by the Georgia CF Core Center will focus on aspects of CF disease central to the mission of the NIDDK, including CF-related diabetes (CFRD), the impact of CF on nutritional status, gastrointestinal function, liver function (including CF-related liver disease, CFLD), and metabolism, and the relationship between these complications of CF disease and lifestyle/behavioral choices such as diet, exercise, activity, and sleep. Led by Georgia CF Core Center Director, Dr. Nael McCarty, the Administrative Core serves to tie the three primary institutions together in pursuit of research that results in new knowledge that is impactful upon CF clinical care. The Administrative Core is responsible for the overall leadership, coordination, and management of the Georgia CF Core Center, including facilitating interactions among investigators and Core users, allocation and oversight of resources, and promoting the Center. The Administrative Core also will serve the needs of the Center Members and the CF patient/family community by providing a high quality Enrichment and Dissemination Program that will be extended to all three primary institutions. We will accomplish these goals through the following Specific Aims and activities: Aim 1. Formulate and implement a strategic plan for shaping, expanding, and optimizing CF research at Emory, Georgia Tech, and Augusta University, and other regional institutions. Rationale: A well-thought out and executed strategic plan is crucial for effective promotion and dissemination of CF research. Aim 2. Provide oversight and direction, monitor progress, and promote growth for all CF research programs and Cores. Rationale: Implementing a synergistic, coordinated, and integrated program for advancing CF research requires high-level administrative direction and oversight. The Center’s effectiveness depends on its ability to use resources wisely, meet its goals, and as necessary, adapt Center goals as research questions, challenges, opportunities, and support needs evolve. Aim 3. Promote interactions and communication between Core Center institutions and investigators. Rationale: Enabling interdisciplinary interactions, collaborations, and effective communication promotes cohesion, creativity, and productivity.