Dakota Cancer Collaborative on Translational Activity

DACCOTA-总体总结 摘要：本基金申请的目的是建立一个中心，以支持和扩大我们的能力， 对各种癌症进行全方位的临床和转化研究。创建Dakota 癌症翻译活动合作组织（DACCOTA）也将首次允许我们应用我们的 将基础科学和流行病学工作应用于临床竞技场，同时培训临床医生-研究者合作伙伴， 翻译这些发现。我们将培训基础科学家进行转化工作， 专家了解癌症结果的社区决定因素，临床医生合作。的 DACCOTA将促进和促进临床医生和科学家之间的互动， 专业知识的互补领域。我们的目标是建立一个高效，协作， 可持续的转化研究中心，将专注于最常见的癌症， 这一问题不成比例地困扰着我们地区的公民，特别是美洲印第安人。我们提出 独立的核心，都由有能力的研究人员领导，这将有助于建立一个有竞争力的临床和 转化癌症研究中心该DACCOTA将提供一个学术家的临床和 翻译科学家和实习生。这些研究人员将专注于了解 导致癌症的发生和发展，这将促进新的和 有效治疗和改善疾病监测。这是必要的，由于癌症的增加 发病率和死亡率在达科他州地区和整个美国。DACCOTA将进一步 通过验证发展和支持个人的新方法来促进基于团队的科学 解决影响该区域的关键问题。我们的专业发展核心将发展有抱负的 研究人员和培训实践“真实的世界”的临床医生成为更热心和有效的合作者。 试点赠款的申请人将被要求提出包括一名研究人员和一名临床医生在内的团队。的 社区包围和外展核心将帮助招募志愿者，寻求有关整体 指导，并与社区领导人合作，指定社区的具体癌症相关问题 对RFA的关注将通过试点项目计划进行。除了社区- 北达科他州大学（UND）、北达科他州州立大学（NDSU）和 南达科他州大学（USD），本提案中的合作医院覆盖了90%以上的 地区，包括家庭和社区医学以及农村和 人口健康。这些机构之间也有三个MPH方案。因此，我们非常 能够进行涵盖整个地区的临床研究。同样，生物统计学， 流行病学和研究设计核心以及临床研究资源和设施核心将 联合收割机，开发新资源，加强临床研究。最后，我们的追踪 和评估核心将使用创新的方法来评估这些新的过程，以及提供 提高效率的建议，并确保成本效益和改善患者安全。UND， NDSU，USD和所有临床合作伙伴都完全致力于确保 DACCOTA即使在CTR补助金结束后。

DACCOTA-Overall Summary Summary: The objective of this grant application is to create a center to support and expand our ability to conduct full-spectrum clinical and translational research on various cancers. Establishing the Dakota Cancer Collaborative on Translational Activity (DACCOTA) will also allow us for the first time to apply our basic scientific and epidemiologic work to the clinical arena while training clinician-investigator partners to translate these discoveries. We will train basic scientists to conduct translational work, population health experts to understand the community determinants of cancer outcomes, and clinicians to collaborate. The DACCOTA will promote and facilitate interactions between clinicians and scientists with unique but complementary areas of expertise. Our goal is to develop a highly productive, collaborative, and sustainable translational research center that will focus on the cancers that most commonly and disproportionately afflict the citizens of our region, especially American Indians. We have proposed independent cores, all led by capable investigators, that will assist in building a competitive clinical and translational cancer research center. The DACCOTA will provide an academic home for clinical and translational scientists and trainees. These investigators will focus on understanding the mechanisms leading to the initiation and progression of cancer, which will facilitate the development of novel and effective treatments and improve disease surveillance. This is necessary due to the increase in cancer prevalence and mortality in the Dakota region and throughout the USA. The DACCOTA will have further impact by validating new ways of developing and supporting individuals to facilitate team-based science addressing critical issues affecting the region. Our Professional Development Core will develop aspiring investigators and train practicing "real world“ clinicians to become more avid and effective collaborators. Applicants for pilot grants will be required to propose teams including an investigator and clinician. The Community Enagement and Outreach Core will help recruit volunteers, seek advice about overall directions, and work with community leaders to designate specific cancer-related issues of community concern for RFA’s that will be funneled through the Pilot Projects Program. In addition to the community- based natures of the University of North Dakota (UND), North Dakota State University (NDSU), and the University of South Dakota (USD), the collaborating hospitals in this proposal cover more than 90% of the region and include multiple innovative departments of family and community medicine as well as rural and population health. There are also three MPH programs between these institutions. Thus, we are superbly positioned to conduct clinical research encompassing the entire region. Similarly, the Biostatistics, Epidemiology, and Research Design Core and the Clinical Research Resources and Facilites Core will combine their strengths and develop new resources to enhance clinical research. Finally, our Tracking and Evaluation Core will use innovative methods to evaluate these novel processes as well as provide suggestions to improve efficiency and ensure both cost-effectiveness and improved patient safety. UND, NDSU, USD, and all clinical partners are fully committed to ensuring the growth and sustainability of the DACCOTA even after the CTR grant ends.