Project-002

摘要：这项赠款申请的目标是创建一个中心，以支持和扩大我们的能力 对各种癌症进行全方位的临床和翻译研究。建立达科他州 癌症合作翻译活动(DACCOTA)也将首次允许我们应用我们的 在临床领域开展基础科学和流行病学工作，同时培训临床医生-研究人员合作伙伴 将这些发现转化为。我们将培训基础科学家进行翻译工作，人口健康 专家了解社区癌症结果的决定因素，并与临床医生合作。这个 DACCOTA将以独特的但 相互补充的专业领域。我们的目标是开发高效、协作和 可持续的转化性研究中心，将专注于最常见和 不成比例地折磨着我们地区的公民，特别是美国印第安人。我们已经提议 独立的核心，全部由有能力的研究人员领导，将帮助建立具有竞争力的临床和 转化型癌症研究中心。DACCOTA将为临床和 翻译科学家和实习生。这些调查人员将专注于了解这些机制 导致癌症的发生和发展，这将促进新的和 有效治疗和改进疾病监测。由于癌症的增加，这是必要的 达科他州地区和整个美国的患病率和死亡率。DACCOTA将进一步 通过验证发展和支持个人的新方法来促进基于团队的科学的影响 解决影响该地区的关键问题。我们的专业发展核心将培养有抱负的人 研究人员和培训执业的“真实世界”的临床医生成为更热情和有效的合作者。 试点资助的申请者将被要求推荐包括一名调查员和临床医生在内的团队。这个 社区管理和外展核心将帮助招募志愿者，寻求有关整体的建议 指导，并与社区领导人合作，指定社区中与癌症相关的具体问题 对RFA的关注将通过试点项目计划体现出来。除了以社区为基础的 北达科他州大学(UND)、北达科他州州立大学(NDSU)和 南达科他大学(美元)，这项计划中的合作医院覆盖了90%以上的 该区域包括多个创新的家庭和社区医疗部门以及农村和 人口健康。这些机构之间还有三个公共汽车时速项目。因此，我们超乎寻常地 定位于在整个地区进行临床研究。同样，生物统计学， 流行病学与研究设计核心与临床研究资源与便利核心意志 结合他们的优势，开发新的资源，以加强临床研究。最后，我们的追踪 评估核心将使用创新的方法来评估这些新的流程，并提供 建议提高效率，确保成本效益和改善患者安全。然后呢， NDSU、美元和所有临床合作伙伴完全致力于确保 DACCOTA即使在CTR拨款结束后也是如此。

Summary: The objective of this grant application is to create a center to support and expand our ability to conduct full-spectrum clinical and translational research on various cancers. Establishing the Dakota Cancer Collaborative on Translational Activity (DACCOTA) will also allow us for the first time to apply our basic scientific and epidemiologic work to the clinical arena while training clinician-investigator partners to translate these discoveries. We will train basic scientists to conduct translational work, population health experts to understand the community determinants of cancer outcomes, and clinicians to collaborate. The DACCOTA will promote and facilitate interactions between clinicians and scientists with unique but complementary areas of expertise. Our goal is to develop a highly productive, collaborative, and sustainable translational research center that will focus on the cancers that most commonly and disproportionately afflict the citizens of our region, especially American Indians. We have proposed independent cores, all led by capable investigators, that will assist in building a competitive clinical and translational cancer research center. The DACCOTA will provide an academic home for clinical and translational scientists and trainees. These investigators will focus on understanding the mechanisms leading to the initiation and progression of cancer, which will facilitate the development of novel and effective treatments and improve disease surveillance. This is necessary due to the increase in cancer prevalence and mortality in the Dakota region and throughout the USA. The DACCOTA will have further impact by validating new ways of developing and supporting individuals to facilitate team-based science addressing critical issues affecting the region. Our Professional Development Core will develop aspiring investigators and train practicing "real world“ clinicians to become more avid and effective collaborators. Applicants for pilot grants will be required to propose teams including an investigator and clinician. The Community Enagement and Outreach Core will help recruit volunteers, seek advice about overall directions, and work with community leaders to designate specific cancer-related issues of community concern for RFA’s that will be funneled through the Pilot Projects Program. In addition to the community-based natures of the University of North Dakota (UND), North Dakota State University (NDSU), and the University of South Dakota (USD), the collaborating hospitals in this proposal cover more than 90% of the region and include multiple innovative departments of family and community medicine as well as rural and population health. There are also three MPH programs between these institutions. Thus, we are superbly positioned to conduct clinical research encompassing the entire region. Similarly, the Biostatistics, Epidemiology, and Research Design Core and the Clinical Research Resources and Facilites Core will combine their strengths and develop new resources to enhance clinical research. Finally, our Tracking and Evaluation Core will use innovative methods to evaluate these novel processes as well as provide suggestions to improve efficiency and ensure both cost-effectiveness and improved patient safety. UND, NDSU, USD, and all clinical partners are fully committed to ensuring the growth and sustainability of the DACCOTA even after the CTR grant ends.