Core C: Biostatistics Bioinformatics Core

项目摘要 生物统计学和生物信息学核心（BBC）的目的是提供一个全面的，多方面的， 生物统计学和生物信息学专业知识的学科资源。英国广播公司的成员将合作 与每个项目的研究人员密切合作，将他们的假设转化为可检验的统计假设 并在调查的各个层面上解决相应的目标。这包括设计基础和动物 实验，管理和维护结果数据，数据分析以及统计和生物信息学 推理，并根据探索和可视化所产生的发现制定新的假设， 综合数据。英国广播公司作为一个联络点，调查人员可以从中提取统计数据， 生物信息学专业知识的规划，管理和分析他们的研究。它还开发、测试和 实现各种统计分析技术，包括数学建模，适用于癌症 research.支持的研究类型包括基础科学和转化研究。的大量 在拟议的研究项目和核心中产生的信息需要基于计算机的工具， 协调工作和管理数据。BBC的主要任务是建立一个 集中式关系数据库系统和数据管理结构，便于输入、存储和 检索由计划项目产生的所有数据，并允许受控的信息交换 在几个项目和核心。所有相关研究者均可获得去识别信息 在这个项目上。由于此核心存储的信息的敏感性，我们将采取 广泛的预防措施，以保护参与者的机密性。所有IRB和HIPAA法规将严格遵守 强制执行。通过向调查人员提供数据访问，共享技术能力，并确保 数据，这一核心的数据管理部分将促进实现项目目标， 鼓励进行超出上述范围的探索性分析。

PROJECT SUMMARY The purpose of the Biostatistics and Bioinformatics Core (BBC) is to provide a comprehensive, multi- disciplinary resource of expertise in biostatistics and bioinformatics. Members of the BBC will collaborate closely with investigators from each project in translating their hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing basic and animal experiments, managing and maintaining the resulting data, data analysis and statistical and bioinformatics inference, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. The BBC serves as a focal point from which investigators may draw statistical and bioinformatics expertise for planning, management and analysis of their studies. It also develops, tests and implements various techniques of statistical analysis, including mathematical modeling, applicable to cancer research. Types of research supported include basic science and translational research. The large volume of information to be generated in the proposed research projects and cores requires computer-based tools for the coordination of efforts and the management of data. The primary role of the BBC will be to establish a centralized relational database system and data management structure that facilitates the entry, storage and retrieval of all data generated by the program project, and permits the controlled exchange of information across the several projects and cores. De-identified information will be available to all investigators associated with this program project. Due to the sensitive nature of the information stored by this Core, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.