2021 and 2023 Alcohol-Induced End Organ Diseases Gordon Research Conference

摘要 酒精滥用是世界上主要的可预防的健康风险之一。酒精的使用和滥用是一个原因 在60多种不同的疾病和伤害中给社会带来了巨大的健康和经济负担 全世界。酒精引起的发病率和死亡率的主要份额可归因于酒精引起的死亡 器官疾病，包括癌症、酒精性肝病、胰腺炎、骨质疏松症、糖尿病、 高血压、缺血性心脏病、心律失常、中风、肺炎和胎儿酒精综合征。饮酒 社会各阶层的疾病都在增加，它们经常与其他疾病协同作用 达到流行比例，包括肥胖、糖尿病、代谢综合征、药物滥用和免疫学 疾病。尽管这一领域在过去20年里取得了重大进展，但潜在的疾病 病因学知之甚少，迫切需要获得新的分子知识。 支持酒精引起的终末器官疾病，以加快诊断、预防和治疗。在……里面 这个R13应用程序，我们正在为戈登研究会议(GRC)酒精诱导的支持而努力 2021年和2023年的末期器官疾病。这是一个比较新的GRC，它是在三年前发起的 2017年和2019年的会议非常成功。GRC模型的开放格式包括共享意义 未发表的作品，并为与同行、新同事和 未来一代的酒精研究人员；这种会议模式非常适合推动该领域 新的高度。酒精性末端器官疾病会议的总体目标是促进开放 讨论研究发展，建立新的科学合作，推动下一代 科学进步。这一GRC满足了现场对持续会议的迫切需求，该会议提出了关键的最近 酒精诱导的终末器官损伤和修复的独特形式的发现，确保有时间进行深入研究 讨论、制定新的方法和启动新的合作。本次会议将提供1) 一个促进对酒精诱导组织前沿研究的公开讨论的论坛 损伤，2)促进下一代酒精和组织损伤调查人员的发展，3)促进 青年和高级调查人员之间的互动，4)促进将塑造未来的想法的交流 酒精和组织损伤社区的指导和5)介绍突破性的技术，以促进 对酒精所致组织损伤的机制的理解。我们展望了关于“酒精”的GRC 诱导性终末器官疾病“将极大地促进当前对其潜在机制的理解 结束器官损伤，刺激制定有效的诊断、预防治疗策略 以及酒精使用障碍的治疗。

Abstract Alcohol misuse is one of the world's leading preventable health risks. Alcohol use and abuse is a causal factor in over 60 different diseases and injuries putting an enormous health and economic burden on societies worldwide. The major share of alcohol-induced morbidity and mortality is attributable to alcohol-induced end organ diseases, including cancer, alcoholic liver disease, pancreatitis, osteoporosis, diabetes mellitus, hypertension, ischemic heart disease, arrhythmias, stroke, pneumonia and fetal alcohol syndrome. Alcohol use disorders are on the rise in all segments of society and they often synergize with other diseases that have reached epidemic proportions including obesity, diabetes, metabolic syndrome, drug abuse and immunological maladies. Despite the significant advances of the field over the last two decades, the underlying disease etiology is poorly understood and there is an urgent need to gain new knowledge of the molecular underpinnings of alcohol-induced end organ diseases to accelerate diagnosis, prevention, and treatment. In this R13 application, we are seeking support for the Gordon Research Conferences (GRC) Alcohol-induced End Organ Diseases 2021 and 2023. This is a relatively new GRC, which was initiated three years ago held extremely successful meetings in 2017 and 2019. The open format of GRC model includes sharing significant unpublished work and provides ample opportunities for in-depth discussions with peers, new colleagues and the future generation of alcohol researchers; this conference model is ideally suited for propelling the field to new heights. The overall goal of the Alcohol-induced End Organ Diseases meetings are to foster open discussion of research developments, establish new scientific collaborations, and propel the next generation of scientific advances. This GRC fills a critical need in the field for a continuing meeting that presents key recent findings on alcohol-induced end organ injury and repair in a unique format that ensures time for in-depth discussions, formulation of new approaches and initiation of new collaborations. This conference will 1) provide a forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of alcohol and tissue injury investigators, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injuries. We envision the GRC on “Alcohol induced end organ diseases” will significantly advance current understanding of the underlying mechanisms of end organ injuries and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol use disorders.