Animal Core

动物核心-耶鲁大学MPMOD 摘要 耶鲁大学肥胖和糖尿病活体模型(MPMOD)代谢表型的总体目标 动物核心是提供最先进的畜牧业、医疗保健、快速隔离和生物安全住房 以及用于评估和维护提交进行表型鉴定的小鼠的程序空间。MPMOD动物核心 将继续驻留在耶鲁动物资源中心(YARC)内，并将在已获得的经验基础上再接再厉 来自代谢表型&10,000只小鼠作为耶鲁大学小鼠代谢表型中心的动物核心 (MMPC)。精确的表型分型在很大程度上取决于动物受试者的健康状况。稳定的住房和 畜牧业将可能影响表型结果和重复性的外源因素的影响降至最低。 提交MPMOD的小鼠将与来自不同微生物来源的队列共享空间。他们，作为 就像饲养在耶鲁居民群体中的小鼠一样，必须保护小鼠免受外来物种的潜在交叉感染 探员们。MPMOD调查人员还必须在老鼠到达开始后不久就准备好接触它们 表型，允许在更小的年龄对动物进行研究，并最大限度地减少与 表型鉴定过程。为了高效和有效地满足这些要求，Animal Core将提供 与以下方面相关的设施和服务：1)使用风险分层方法进口小鼠进行代谢表型鉴定； 2)确定每个进口队列的微生物谱(在两周内)；3)提供稳定的， 为小鼠提供生物围栏住房、饲养和全面保健，持续时间为 表型测试；4)向MPMOD客户、核心/次核心总监和MPOD总监提供报告和建议 提交的小鼠的健康状况，并促进其他可能适用的服务 表型鉴定。动物核心还将参与制定/修订MPMOD联盟的指导方针 照顾动物。

Animal Core- Yale MPMOD Summary The overall objective of the Yale Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD) Animal Core is to provide state-of-the-art husbandry, health care, expedited quarantine, and biosecure housing and procedure space for assessing and maintaining mice submitted for phenotyping. The MPMOD Animal Core will continue to reside within the Yale Animal Resources Center (YARC) and will build on the experience gained from metabolic phenotyping > 10,000 mice as the Animal Core for Yale’s Mouse Metabolic Phenotyping Center (MMPC). Precise phenotyping depends significantly on the health status of animal subjects. Stable housing and husbandry minimize the influence of exogenous factors that could impact phenotyping results and reproducibility. Mice submitted to the MPMOD will share space with cohorts from microbiologically diverse sources. They, as well as mice housed in resident Yale colonies, must be protected against potential cross-infection by adventitious agents. MPMOD investigators also must have ready access to the mice soon after they arrive to begin phenotyping, allowing animals to be studied at younger ages and minimizing costs associated with the phenotyping process. To address these requirements efficiently and effectively, the Animal Core will provide facilities and services relevant to: 1) importing mice for metabolic phenotyping using a risk stratified approach; 2) determining the microbiological profile of each imported cohort (within two weeks); 3) providing stable, biocontainment housing, husbandry and comprehensive health care for mice for the duration required for the phenotyping exam; 4) reporting and advising MPMOD clients, Core/Sub-Core Directors and MPOD Director on the health status of submitted mice and to facilitate other potentially applicable services available to advance phenotyping. The Animal Core will also participate in developing/revising MPMOD consortium guidelines for animal care.