Excitable Networks in Directed Cell Migration

定向细胞迁移在发育和许多生理过程中都是至关重要的。 成人如伤口愈合和免疫反应。它也在病理性疾病中起着关键作用。 像癌症转移这样的事件。我们的实验室研究细胞迁移已有40多年的历史。作为一名 作为我们Mira赠款的补充，我们正在申请资金以购买Total Internal Reflect 具有超分辨能力的荧光显微镜。正如研究计划中所描述的， 仪器对于成像我们在研究中使用的许多生物传感器是必不可少的。这台仪器 我们目前有15年的历史，缺乏现代技术，这将大大 方便我们的学习。我们在原文中忽略了对这一工具的需求 米拉续期申请书。 这一工具约为254337美元。我要求200000美元作为我的 米拉·格兰特。细胞生物系将提供54337美元的机构支助(见 埃瓦尔德博士的来信)。

Directed cell migration is critical in development and in numerous physiological processes in the adult such as wound healing and immune response. It also plays a critical role in pathological events like cancer metastasis. Our lab has been studying cell migration for over 40 years. As a supplement to our MIRA grant, we are requesting funds to purchase a Total Internal Reflection Fluorescence Microscope with superresolution capability. As described in the research plan this instrument is essential for imaging the many biosensors we use in our studies. The instrument we have available currently is 15 years old and lacks the modern technology that would greatly facilitate our studies. We neglected to consider the need for this instrument in the original application for renewal of the MIRA. The instrument is approximately $254337. I am requesting $200000 as a supplement to my MIRA grant. The Department of Cell Biology will provide institution support of $54337 (see letter from Dr. Ewald).