WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research Facilities

项目摘要/摘要 家长补助(P51OD011106)。威斯康星州国家灵长类研究中心(WNPRC)是七个中心之一 联邦政府资助的国家灵长类动物研究中心，也是中西部唯一的研究中心。WNPRC的使命是 增加对灵长类基本生物学的了解，并通过 研究。为了实现这一目标，WNPRC帮助发现人类疾病的治疗方法、预防和治愈方法； 产生灵长类生物学的新知识，从分子和整个动物水平到理解 指灵长类生态系统；通过向科学家提供专业知识、资源和培训来促进研究进展 并收集灵长类动物的信息，并向研究界和公众传播。 行政副刊。WNPRC支持一大批调查人员利用猿猴 免疫缺陷病毒(SIV)和猴/人免疫缺陷病毒(SHIV)感染的恒河猴和 食蟹猴作为人类免疫缺陷病毒(HIV)感染和获得性感染的模型 免疫缺陷综合征(艾滋病)。2019年，WNPRC获得C06资金，建设新的传染病 疾病套间由七个猕猴休息室和一个程序室组成，旨在支持各种 通常对感染SIV/SIV病毒的猕猴进行的程序，以及适当的饲养支持 太空。这项P51行政补充提案的单一、直截了当的具体目标是确保 为购买最先进的非人类灵长类动物围栏的一大部分提供资金 有必要装备新的传染病套件，因为新冠肺炎大流行大大减少了财政 中心计划用来购买这些盘柜的储备。

Project Summary/Abstract Parent grant (P51 OD011106). The Wisconsin National Primate Research Center (WNPRC) is one of seven federally funded National Primate Research Centers and the only one in the Midwest. WNPRC's mission is to increase the understanding of basic primate biology and to improve human health and quality of life through research. To accomplish this, the WNPRC helps discover treatments, preventions and cures for human disease; generates new knowledge of primate biology, from the molecular and whole animal levels to the understanding of primate ecosystems; facilitates research progress by providing expertise, resources and training to scientists worldwide; and collects primate information and disseminates to the research community and to the public. Administrative Supplement. The WNPRC supports a large cadre of investigators utilizing the simian immunodeficiency virus (SIV) and the simian/human immunodeficiency virus (SHIV)-infected rhesus and cynomolgus macaque as models of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). In 2019, the WNPRC obtained C06 funding to construct a new infectious disease suite consisting of seven macaque holding rooms, one procedure room engineered to support a variety of procedures commonly performed with SIV/SHIV infected macaques, as well as appropriate husbandry support space. The single, straightforward, specific aim of this P51 administrative supplement proposal is to secure funding to purchase a substantial portion of state-of-the-art mobile “four-bank” nonhuman primate enclosures necessary to equip the new infectious disease suite as the COVID-19 pandemic has greatly reduced the financial reserves the Center planned to utilize to purchase these enclosures.