Metabolomics Service

代谢组学服务共享资源 项目摘要/摘要 新泽西州罗格斯癌症研究所代谢组学服务共享资源(代谢组学) (CINJ)是癌症中心管理的共享资源，其目的是实现对 癌症新陈代谢。 在过去的十年里，人们对肿瘤新陈代谢的兴趣激增，这是由于人们认识到癌基因 某些代谢物本身会引起癌症(“肿瘤代谢物”)。这个 最成熟的代谢物2-羟基戊二酸的发现涉及到 乔舒亚·拉比诺维茨，这个代谢组学的主管，分享了资源。共享资源的使命是双重的： 1)继续推动肿瘤代谢测量的前沿，使更多这样的科学 重大影响癌症诊断和治疗的发现；2)为CINJ成员提供简单、 以经济高效的方式使用这些功能，从而提高整个财团的工作效率。为此， 共享资源提供对基本新陈代谢测量能力的访问，如耗氧量、 其中包括容易共享的乐器(例如，海马琴)。它还提供更先进的服务， 例如用LC-MS进行大规模的代谢物定量测定。此外，它还开发和协作 应用尖端新陈代谢测量功能，这些功能是独一无二的或仅在少数情况下可用 世界各地的机构(例如，使用同位素对体内肿瘤-宿主代谢相互作用的定量分析 示踪剂)。 该联盟癌症中心建立在2011年开始的非正式合作基础上，得到了以下方面的支持 CCSG发展基金，建立了CCSG支持的代谢组学发展共享资源。 这种共享资源涉及罗格斯大学和普林斯顿大学的大量投资，形式为 每所大学购买的多种乐器。这种共享资源不仅满足了现有的 代谢分析，但也鼓励研究人员，通过各种方案平台，追求 癌症新陈代谢研究。 《MSR》，第1页，共1页；草案于18-01-18 8：28 AM 好了！

METABOLOMICS SERVICE SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Metabolomics Service shared resource (Metabolomics) of the Rutgers Cancer Institute of New Jersey (CINJ) is a Cancer Center managed shared resource whose purpose is to enable state-of-the-art analysis of cancer metabolism. The past decade has seen a surge of interest in tumor metabolism, driven by the recognition that oncogenes up-regulate metabolism and that certain metabolites can themselves cause cancer (“oncometabolites”). The discovery of the best-established oncometabolite, 2-hydroxyglutarate, involved a central contribution from Joshua Rabinowitz, Director of this Metabolomics shared resource. The shared resource’s mission is two-fold: 1) to continue to push the frontiers of tumor metabolism measurement, enabling additional such scientific discoveries that significantly impact cancer diagnosis and therapy and 2) to provide CINJ members with easy, cost-effective access to these capabilities, thereby enhancing productivity across the consortium. To this end, the shared resource provides access to basic metabolism measurement capabilities, like oxygen consumption, which involve instruments that are readily shared (e.g., Seahorse). It also provides more advanced services, such as large-scale quantitative metabolite measurement by LC-MS. In addition, it develops and collaboratively applies cutting-edge metabolism measurement capabilities that are unique or available in only a handful of institutions world-wide (e.g. quantitative analysis of tumor-host metabolic interplay in vivo using isotope tracers). Building from informal collaborations that started in 2011, the consortium cancer center, with support from CCSG Developmental Funds, established a CCSG-supported developing shared resource for Metabolomics. This shared resource involved substantial investments by both Rutgers and Princeton Universities, in the form of multiple instruments purchased by each university. This shared resource not only met the existing need for metabolic analysis, but also encouraged investigators, through a variety of programmatic platforms, to pursue cancer metabolism research. MSR, Page 1 of 1; DRAFT 1/18/18 8:28 AM !