Core B-Clinical Core

核心B：临床核心 项目摘要/摘要 UCI ADRC临床核心项目招募、描述和跟踪了一群认知能力较强的个体 未受损、认知受损或精神错乱，每个人都完成了统一数据集(UDS)，包括 体检和神经学检查，以及一系列神经认知评估。除了这个UDS， 参与者和他们的研究伙伴完成我们ADRC独有的问卷和评估，以及 自愿提供各种组织和生物标记物评估，包括遗传分析、体积分析 影像、脑脊液分析和成纤维细胞捐献用于诱导多能干细胞的生成 细胞(IPSC)。总体而言，我们目前330名活跃参与者中有292人捐献了成纤维细胞或外周血 单个核细胞(PBMC)，我们的IPSC Core已经使用它们产生了192个IPSC系。多数 参与者同意在尸检时捐献大脑，我们的尸检成功率很高 死亡确认。我们的UDS队列目前包括330名活跃参与者。在这群人中，60%是 女性和三分之一的人是非白人或西班牙裔。19%的人精神错乱，18%的人 轻度认知障碍(MCI)的诊断标准，大多数(60%)不符合MCI或 痴呆症。我们的总体留存率非常高，高于ADRC系统的中位数。大多数UDS 参与者参加了外部资助的辅助研究，范围从电话访谈研究 神经影像生物标记物研究。以支持ADRC调查人员日益增长的需求，包括New 分子和血管生物标记物的研究，我们将使这个UDS队列增长到稳定状态n=400，具有 重点招收能够进行新颖研究以支持UCI ADRC主题的个人，以确定， 量化并验证影响整个生命周期内AD风险的因素。

Core B: Clinical Core Project Summary/Abstract The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS, participants and their study partners complete questionnaires and assessments unique to our ADRC, and voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify, quantify, and validate factors that influence the risk of AD across the lifespan.”!