Boston Area Diabetes and Endocrinology Research Center (BADERC)

摘要 波士顿地区糖尿病内分泌研究中心是一个由 实验室和临床研究人员，他们的努力旨在解决主要的 I型和T型的病因、发病机制及治疗研究问题 2糖尿病及其相关的微血管和大血管并发症。《中心》 导演(何塞·弗洛雷斯)和副导演(芭芭拉·卡恩和亚历山大·苏卡斯)高度 富有成效的具有国际地位的高级调查人员。与会科学家，与 糖尿病相关赠款支持的年度直接成本合计超过1.1亿美元，其基础是 波士顿地区的各种研究机构，包括哈佛医学院附属的主要研究机构 教学医院(马萨诸塞州总医院、贝丝以色列女执事医疗中心 中心、布里格姆妇女医院、波士顿儿童医院)和研究机构 (公共卫生学院，达纳-法伯癌症研究所，博德研究所)，波士顿 大学医疗中心和塔夫茨新英格兰医疗中心。这些调查人员是 在与定义发病机制和最佳方案最相关的领域的前沿工作 1型和2型糖尿病的治疗，如1)胰岛素作用的分子基础和 胰岛素抵抗；2)能量平衡的神经生物学；3)免疫学基础和最佳 自身免疫和移植排斥反应的治疗；4)糖尿病的遗传结构和 相关特征；5)血糖监测和控制新方法的发展。这个 BADERC为这些科学家提供丰富计划和一系列核心支持服务 (细胞生物学、转基因动物、代谢生理学)，结合了最新的技术 分子遗传学、细胞生物学和代谢生理学的研究进展 认可专家，并提供实践培训。临床研究和研究领域的新核心 生物信息学在这一应用中应运而生。BADERC调查人员也收到了便利的 访问博德研究所的几个平台(基因组学、蛋白质组学、代谢组学、 成像、基因编辑)。BADERC还提供订阅量很高且成功的试点项目& 可行性资助计划，BADERC调查人员支持暑期医学生 研究经验。轻松获得高质量、经济高效的支持服务， 与教育和试点赠款计划一起，促进了许多合作，以及 吸引了这一杰出科学界的新人才进入糖尿病研究。最后， 中心致力于促进实验室和临床之间最密切的互动 科学家，以确保将研究发现转化为护理方面的进展 糖尿病患者。

ABSTRACT The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing the major research questions bearing on the etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and macrovascular complications. The Center Director (Jose Florez) and Associate Directors (Barbara Kahn and Alexander Soukas) are highly productive senior investigators of international stature. The 64 participating scientists, with combined annual direct costs in excess of $110M in diabetes-related grant support, are based at various Boston-area research institutions, including the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, the Brigham and Women's Hospital, Boston Children’s Hospital) and research institutes (the School of Public Health, Dana-Farber Cancer Institute, the Broad Institute), the Boston University Medical Center, and the Tufts New England Medical Center. These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of type 1 and type 2 diabetes, such as 1) the molecular basis of insulin action and insulin resistance; 2) the neurobiology of energy balance; 3) the immunologic basis and optimal therapies for autoimmunity and transplant rejection; 4) the genetic architecture of diabetes and related traits; and 5) the development of new methods for glycemic monitoring and control. The BADERC offers these scientists an Enrichment Program and an array of core support services (Cell Biology, Transgenic Animals, Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts and provide hands-on training. New Cores in Clinical Investigation and Bioinformatics are proposed in this application. BADERC investigators also receive facilitated access to several platforms of the Broad Institute (Genomics, Proteomics, Metabolomics, Imaging, Gene editing). The BADERC also offers a highly subscribed and successful Pilot & Feasibility grant program, and BADERC investigators support summer medical students for a research experience. The easy access to cost-effective support services of outstanding quality, together with the educational and pilot grants program, have promoted many collaborations, and attracted new talent from this outstanding scientific community to diabetes research. Finally, the Center strives to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of patients with diabetes.