Hawaii Pacific Islands Mammography Registry

项目总结/摘要 尽管最近在早期发现和治疗方面取得了进展，但乳腺癌仍然是发病的主要原因 and mortality.夏威夷土著妇女在夏威夷的乳腺癌发病率最高， 有利的繁殖模式。日裔美国女性现在经历着与美国女性相同的乳腺癌风险。 非西班牙裔白色女性此外，亚裔美国人的晚期乳腺癌发病率相当高 与美国本土相比，夏威夷和太平洋地区的女性比例为15%对9%。侵入性的绝对风险 癌症和晚期癌症在这些美国人群中的发生率尚不清楚。我们的长期目标是 开发准确和有效的乳腺癌风险生物标志物，有助于筛查策略， 具有不同乳腺癌风险特征的亚洲人群，迄今为止，乳腺癌风险特征在乳腺癌中的代表性不高。 癌症队列和临床试验。夏威夷太平洋岛屿乳腺X线摄影登记处（HIPIMR）将是一个 资源，以确定和验证该地区不同种族群体的新图像生物标志物， 不同的风险因素概况，包括夏威夷原住民，日本人，菲律宾人，中国人和其他种族群体。 结合San弗朗西斯科乳腺X射线摄影登记研究和HIPIMR队列，我们将获得统计学把握度， 描述亚洲人群中侵袭性和晚期癌症的风险。我们的中心假设是标准乳房 癌症危险因素和图像因素及其患病率在不同人群中是不同的， 集中在太平洋地区（夏威夷、关岛、美属萨摩亚）和美国大陆的亚洲族裔群体 与非西班牙裔白色、非西班牙裔黑人和西班牙裔女性相比。我们计划验证一个假设 使用亚洲人群的风险因素概况和下一代乳房组成和纹理特征， 美国人口中增长最快的部分，9和NHPI种族群体将改善癌症风险预测。 我们的具体目标是与非西班牙裔白色妇女相比：1。检查临床风险因素及其 亚洲接受乳腺癌筛查的女性与浸润性和晚期乳腺癌的相关性 （日本人，菲律宾人，中国人）和夏威夷太平洋岛民（AANHPI）血统，2。下一个- 从2D和3D乳腺X射线摄影生成乳腺成像特征，包括体积乳腺密度， 钙化、肿块、纹理特征及其与浸润性和晚期乳腺癌的相关性， AANHPI妇女，使用先进的人工智能和机器学习方法，3。识别 与浸润性和晚期乳腺癌风险相关的临床风险因素和影像学因素的组合 在AANHPI妇女中。本研究解决了准确识别定义的临床和 AANHPI人群中的放射组学危险因素及其与乳腺癌风险的关系，以改善结局 对这些女人来说。

PROJECT SUMMARY / ABSTRACT Despite recent advances in early detection and treatment, breast cancer remains a major cause of morbidity and mortality. Native Hawaiian women have the highest breast cancer incidence in Hawaii despite their favorably reproductive patterns. Japanese American women now experience the same breast cancer risk as non-Hispanic White women Further, advanced breast cancer rates are considerably higher in Asian American Women in Hawaii and the Pacific compared to the US mainland, 15% versus 9%. The absolute risk of invasive cancer and advanced cancer in these groups of the US population is not known. Our long-term goal is to develop accurate and validated breast cancer risk biomarkers that can contribute to screening strategies for Asian groups with diverse breast cancer risk profiles who to date have not been well represented in breast cancer cohorts and clinical trials. The Hawaii Pacific Islands Mammography Registry (HIPIMR) will be a resource to identify and validate novel image biomarkers for the diverse ethnic groups of this region with varying risk factor profiles including Native Hawaiians, Japanese, Filipino, Chinese, and other ethnic groups. Combining San Francisco Mammography Registry and HIPIMR cohorts will give us the statistical power to describe risk of invasive and advanced cancer in Asian groups. Our central hypothesis is that standard breast cancer risk factors and image factors and their prevalence are different in the diverse populations found in high concentrations in the Pacific (Hawaii, Guam, American Samoa) and Asian ethnic groups in the mainland US compared to non-Hispanic White, non-Hispanic Black and Hispanic women. We plan to test the hypothesis that using risk factor profiles and next generation breast composition and texture features across Asian groups, the fastest growing segment of the US population,9 and NHPI ethnic groups will improve cancer risk prediction. Our specific aims are as compared to non-Hispanic White women: 1. Examine clinical risk factors and their association with invasive and advanced breast cancer in women undergoing breast cancer screening by Asian (Japanese, Filipino, Chinese) and Native Hawaiian Pacific Islander (AANHPI) ancestry, 2. Identify next- generation breast imaging characteristics from 2D and 3D mammography, including volumetric breast density, calcifications, masses, texture features and their association with invasive and advanced breast cancer for AANHPI women, using advanced artificial intelligence and machine learning approaches, 3. Identify the combination of clinical risk factors and image factors associated with invasive and advanced breast cancer risk among AANHPI women. This study addresses the need for accurate identification of defined clinical and radiomic risk factors among AANHPI populations and their relation to breast cancer risk to improve outcomes for these women.