Animal Core

抽象动物核心 该中心的目标是提供复杂的代谢、生理和行为表型分析以及 提供咨询服务，在公平的收费基础上描述活着的老鼠模型。要做到这一点，需要 中心接收、安置、喂养、监测和维护提交进行表型鉴定的小鼠的健康 调查人员。因此，动物芯将进口并提供最佳的畜牧业护理和高品质 动物卫生服务中心为送来并登记参加检测的小鼠提供多项专业 应要求提供包括手术操作服务、分子和病理学在内的服务，并使 从存储库访问与疾病相关的小鼠模型或派生和创建糖尿病小鼠模型 和/或肥胖症在该中心进行测试。动物核心将由一名领队、联合领队和 核心协调员。 动物核心将通过追求以下三个具体目标来完成其使命： 具体目标1：接收、安置、喂养、监测和维持小鼠的健康。 具体目标2：管理、组织和协调小鼠的运动以进行表型鉴定。 具体目标3：将该中心的使用扩大到有或没有老鼠的研究人员。 动物核心将拥有进口和适应MICE会议的机构资源和权力 某些最低健康标准，用于进一步的表型分析，并最大限度地延迟进入专用 设施。这种高通量和多功能的核心将扩大代谢模型和 通过使研究人员的小鼠能够被分析，加快数据生成和解释， 并最终以合理的成本及时完成测试项目。

ABSTRACT—ANIMAL CORE The goal of the Center is to provide complex metabolic, physiologic, and behavioral phenotyping and consulting services to characterize living mouse models on a fair fee-for-service basis. To do so requires a Center to receive, house, feed, monitor, and maintain the health of mice submitted for phenotyping by investigators. Therefore, the Animal Core will import and provide optimal husbandry care and high-quality animal health services for mice sent and enrolled for testing at the Center, provide a number of specialty services, including surgical manipulation services, molecular, and pathology, upon request, and make facilitate access to disease-relevant mouse models from repositories or derive and create mouse models of diabetes and/or obesity de novo for testing at the Center. The Animal Core will be staffed by a Leader, co-Leader, and Core Coordinator. The Animal Core will fulfill its mission by pursuing the following 3 Specific Aims: Specific Aim 1: Receive, house, feed, monitor and maintain health of mice. Specific Aim 2: Manage, organize, and coordinate movement of mice for phenotyping. Specific Aim 3: Expand utilization of the Center to investigators with or without mice. The Animal Core will have the institutional resources and authority to import and acclimate mice meeting certain minimal health standards for further phenotypic analysis with minimal delay into dedicated vivarium facilities. This high-throughput and multifunctional Core will broaden the availability of metabolic models and phenotyping tests by enabling investigator mice to be analyzed, expediting data generation and interpretation, and ultimately complete testing projects in a timely fashion and for reasonable cost.