Basic Science Core - Animal models

TRAC内动物核心摘要 动物模型核心将建立一个培训计划，向所有TRAC参与者介绍结核病领域 使用各种动物模型，可以将硅胶和体外研究结果转化为潜在的应用 人类。德克萨斯州生物医学中心拥有西南国家灵长类动物研究中心(SNPRC)，并已开发出 大型NHP项目，融合了空气生物学、分子生物学和各种成像平台 动物生物安全3级(ABSL3)。这些将成为动物核心的基础。具体目标1： 开展利用动物进行研究和替代的教育项目。动物的使用 在研究中需要考虑三个R(减少、替换、细化)。所有TRAC内参与者 将在实验设计过程中接受三个R的考虑，选择合适的 测试其特定假设的模型，以及可用于或正在开发的替代系统 在生物医学研究中替代动物。具体目标2：利用结核病的小鼠模型 研究发病机制和新疗法和疫苗的测试。老鼠模型一直是 结核病研究和仍然是一个有用的工具，以了解结核病免疫发病机制和筛选药物和 结核病疫苗。将向TRAC参与者介绍各种可用于结核病的鼠标资源 研究，并将接受如何利用啮齿动物设计和进行研究以及如何进行研究的理论和实践培训 用科学的严谨来解释实验数据。具体目标3：利用结核病的NHP模型进行研究 新疗法和疫苗的发病机制和测试。德克萨斯生物制药公司拥有独特的资源， SNPRC，可以为TRAC参与者提供在结核病研究中使用NHP的深入培训。在- TRAC参与者将被介绍给可用于结核病研究的各种国家卫生规划资源，并进行理论培训 以及如何使用NHP设计和进行研究，以及如何使用NHP解释实验数据的实践 科学的严谨性。在动物模型核心完成后，参与者将能够有效地解释 发表了使用啮齿动物和NHP(以及其他动物模型，部分通过外部飞船)的数据，设计 实验验证他们自己的假设，并参与使用动物进行的结核病研究。

IN-TRAC ANIMAL CORE ABSTRACT The Animal Model Core will establish a training program to introduce all IN-TRAC participants to the TB field using a variety of animal models that can translate in silico and in vitro findings into potential application to humans. Texas Biomed hosts the Southwest National Primate Research Center (SNPRC) and has developed large NHP programs that incorporate aerobiology, molecular biology and a variety of imaging platforms within the Animal Biosafety Level 3 (ABSL3). These will be the foundation of the Animal Core. SPECIFIC AIM 1: Conduct an educational program in the use of animals for research, and alternatives. The use of animals in research requires consideration of the three R’s (reduction, replacement, refinement). All IN-TRAC participants will receive training in the considerations of the three R’s during experimental design, selection of appropriate models to test their specific hypothesis, and the alternate systems available or in development for the replacement of animals in biomedical research. SPECIFIC AIM 2: Leveraging the mouse model of TB to study pathogenesis and testing of new therapies and vaccines. The mouse model has been a mainstay for TB research and remains a useful tool for understanding TB immuno-pathogenesis and for screening drugs and vaccines for TB. IN-TRAC participants will be introduced to a variety of mouse resources available for TB research, and will be trained in theory and practice of how to design and conduct studies using rodents, and how to interpret experimental data with scientific rigor. SPECIFIC AIM 3: Leveraging the NHP model of TB to study pathogenesis and testing of new therapies and vaccines. Texas Biomed has a unique resource in the SNPRC that can provide IN-TRAC participants with an in depth training in the use of NHPs in TB research. IN- TRAC participants will be introduced to a variety of NHP resources available for TB research, and train in theory and practice of how to design and conduct studies using NHPs, and how to interpret experimental data with scientific rigor. At the completion of the Animal Model Core, participants will be able to effectively interpret published data that use rodents and NHP (and other animal models, in part through externships), design experiments to test their own hypothesis, and participate in TB research that uses animals.