Research Project 3

现在测试教育计划（调整）。 项目摘要 非裔美国人的结直肠癌（CRC）发病率和死亡率高于非西班牙裔美国人 白人虽然美国各地的CRC癌症死亡率有所下降，但在南方各州， 与其他地区相比，速度更慢。CRC癌症死亡可以通过增加CRC筛查来预防。 流行病学数据表明，与白人相比，非洲裔美国人的癌症健康差异。解决 这些差异，这项研究项目将测试社区健康顾问（CHA）的有效性 教育干预，以增加非裔美国人的CRC筛查。根据一项 一项针对非裔美国人的CRC筛查随机试验，使用个人电话进行患者教育 呼叫和导航有效地增加了约18%的筛查（科尔等人，2017）。我们的研究 一种假设是，一种创新的CHA干预，使用国家癌症研究所的改编版本， 屏幕以保存材料，并结合亲自，电话联系和短信将增加CRC 与未接受治疗的对照组相比，未依从治疗的患者中的筛查率为15%或以上 CHA的干预。将通过追求三个具体目标来检验假设。第一个目标是评估 CHA干预在非裔美国人样本中增加CRC筛查的有效性 他们没有及时接受筛查。第二个目的是探讨干预对中介人的影响 以及与接受CRC筛查相关的调节变量。第三个目标是进行成本- 人道协调厅干预措施的有效性分析。将从社区招募两名非裔美国人查 进行干预本研究项目提出了一个随机、双臂、平行研究设计， 比较CHA干预对接受CRC筛查后3个月和12个月的影响， 干预组与“仅提供信息”的对照组进行比较。主要结果是收到任何 CRC筛查的模式（例如，结肠镜检查或粪便免疫化学试验，FIT）。研究人员还将 检查干预措施的可接受性以及其他指标（知识，自我效能， 筛选意向和CRC筛选偏好）。这项研究的潜在影响将是实施 并传播干预措施，以增加非裔美国人中的CRC筛查，这是低成本的， 有效，易于实施。研究结果将有助于筛选干预措施的研究领域 通过与其他使用临床导向方法和其他面向客户的干预措施的研究进行比较。 该项目的长期目标是为未来使用多个地点进行有效性试验提供依据， 佛罗里达经历CRC的健康差距，并检查在系统范围内设置的实施物流。

Test Up Now Education Program (TUNE-UP). Project Summary African Americans experience higher incidence and mortality from colorectal cancer (CRC) than non-Hispanic whites. While CRC cancer death rates across the US have declined, in Southern states the decline has been slower compared to other regions. CRC cancer deaths could be prevented with increased CRC screening. Epidemiological data indicate cancer health disparities for African Americans compared to whites. To address these disparities, this research project will test the effectiveness of a Community Health Advisor (CHA) educational intervention to increase CRC screening among African Americans. According to the results of a randomized trial focused on CRC screening for African Americans, patient education using a personal phone call and navigation effectively increased screening by approximately 18% (Cole et al. 2017). Our research hypothesis is that an innovative CHA intervention using an adapted version of the National Cancer Institute Screen to Save materials and combining in-person, phone contact, and text messaging will increase CRC screening among those who are non-adherent by 15% or more compared to a control group who do not receive the CHA intervention. The hypothesis will be tested by pursuing three Specific Aims. The first aim is to evaluate the effectiveness of a CHA intervention for increasing CRC screening among a sample of African Americans who are not up-to-date with screening. The second aim is to explore the effect of the intervention on mediator and moderator variables associated with the receipt of CRC screening. The third aim is to conduct a cost- effectiveness analysis of the CHA intervention. Two African American CHAs will be recruited from the community to deliver the intervention. This research project proposes a randomized, two-arm, parallel study design to compare the effect of a CHA intervention on receipt of CRC screening after three and 12 months in the intervention group compared to an “information-only” control group. The primary outcome is receipt of any modality of CRC screening (e.g., colonoscopy or fecal immunochemical test, FIT). The researchers will also examine acceptability of the intervention as well as changes in other indicators (knowledge, self-efficacy, intention to screen and CRC screening preferences). The potential impact of this study will be the implementation and dissemination of an intervention to increase CRC screening among African Americans that is low-cost, effective, and easily implemented. The results will contribute to the research area of screening interventions through comparisons with other studies using clinic-oriented approaches and other client-oriented interventions. The project’s long-term objective is to provide justification for a future effectiveness trial using multiple sites in Florida experiencing CRC health disparities and examine implementation logistics in system-wide settings.