Role of Structural Remodeling in Atrial Fibrillation

7.项目总结 目前对持续性房颤(房颤)的治疗与高复发率相关，这是由于我们的 了解房颤是如何发展和维持的。在房颤患者中，结构重建以纤维化的形式出现 提示结构重塑可能在房颤的发生发展中起一定作用。该项目旨在 通过转基因山羊模型确定纤维化在房颤中的作用。在目标1中，我们努力表明 房颤发生过程中结构重构与电重构的比较。在目标2中，结构的体系结构 将对重建进行调查，以确定潜在纤维化结构的差异是否会导致 房颤易感性。在目标3中，纤维化结构将与体内电标测数据进行比较，以 确定不同程度的纤维化如何影响传导模式。这个项目的结果将调查 结构重塑和传导受损之间是否存在因果关系。在这个项目中取得成功 这将改善持续性房颤患者的消融目标，降低复发率。 该项目的完成为发展成为独立的 研究员。

7. Project Summary Current treatments for persistent atrial fibrillation (AF) are associated with high recurrence rates due to our limited understanding of how AF develops and sustains. In patients with AF, structural remodeling in the form of fibrosis is often present, indicating that structural remodeling may have a role in AF development. This project aims to identify the role of fibrosis in AF by using a transgenic goat model. In aim 1, we strive to show the importance of structural remodeling compared to electrical remodeling in AF developing. In aim 2, the architecture of structural remodeling will be investigated to identify if differences in the underlying fibrotic architecture lead to increased AF susceptibility. In aim 3, the fibrotic architecture will be compared to in-vivo electrical mapping data to determine how varying degrees of fibrosis affect conduction patterns. The results of this project will investigate if there is a causal relationship between structural remodeling and impaired conduction. Success in this project will lead to improved ablation targets for patients with persistent AF, leading to lower recurrence rates. Completing this project provides valuable scientific and technical training to develop into an independent researcher.