Pediatric Cardiovascular and Pulmonary Research Training Program

项目总结/摘要 这是一个非常成功的计划，旨在吸引和培养博士前和博士后的更新申请。 儿童心、肺相关疾病基础研究博士后 生物学心血管和肺血管疾病的细胞和分子基础培训计划的必要性 疾病，特别是对儿童疾病感兴趣的医生科学家，是基于明确的证据， 在教员和受训人员两级，这种人的国家储备都在下降。目前，少数儿童 美国医疗中心的心脏病学或肺学奖学金计划提供了足够的培训， 研究领域，无论是在实验室还是在结构化临床研究中。我们的计划旨在解决 这需要从两个重要的角度：1）让儿科和其他临床研究员有兴趣在 基础研究，发展研究能力和职业培训; 2）吸引和培养基础人才 在博士前和博士后水平的科学家，研究与心肺疾病有关的机制， 童年.我们的计划是根据上一个计划的评审员的反馈， 我们的教师和项目顾问，由过去的学员，并列入新的教师和核心课程，在 华盛顿大学，使我们能够扩大我们的学员的培训经验。除了继续 我们在发育/细胞生物学和疾病的分子基础方面的强大训练，拟议的计划将 利用遗传学、干细胞生物学、基因组学和生物信息学方面的机构优势， 这是现代研究的基础。此外，我们有一个新纳入的重点 心肺系统感染是全球儿科发病率和死亡率的主要原因。我们 保持了4个博士后和2个博士前研究员的培训课程， 一年的全职调查。这一重点得到了多学科核心教学研讨会的加强， 杂志俱乐部和正式的课程，是专为每个学员通过咨询与 指导/项目管理员提供心肺关键方面的个性化教育 发展和疾病。我们的目标是：1）为学员提供广泛的职业指导 发展和发展专注于儿科疾病的独立研究计划; 2）促进 基础细胞和分子生物学，基因组学和生物信息学以及临床翻译培训 3）指导学员的发展，使学员在完成培训后， 可能会出现对独立供资的竞争。

PROJECT SUMMARY/ABSTRACT This is a renewal application for a high successful program designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of childhood diseases related to cardiovascular and pulmonary biology. The need for a training program in the cellular and molecular basis of cardiovascular and pulmonary disease, especially of physician scientists interested in childhood diseases, is based upon clear evidence of a declining national pool of such individuals at both the faculty and trainee levels. Currently, few pediatric cardiology or pulmonary fellowship programs in American medical centers provide adequate training in this area of research, either at the bench or in structured clinical investigation. Our program is designed to address this need from two important perspectives: 1) To allow pediatric and other clinical fellows with an interest in basic research to develop research competence and career training; 2) To attract and train talented basic scientists at the pre- and post-doctoral levels to study mechanisms related to cardiorespiratory disease in childhood. Our program has been shaped by feedback from reviewers of the previous program, by advice from our faculty and program advisors, by past trainees, and by the inclusion of new faculty and core programs at Washington University that allow us to expand the training experience of our trainees. In addition to continuing our strong training in developmental/cell biology and the molecular basis of disease, the proposed program will take advantage of institutional strengths in genetics, stem cell biology, genomics, and bioinformatics—all of which are components of the foundation of modern research. In addition, we have a newly incorporated focus on infection of the cardiorespiratory system, a leading cause of pediatric morbidity and mortality worldwide. We have maintained a training curriculum for 4 postdoctoral and 2 predoctoral fellows with an uninterrupted 2-3 year block of full-time investigation. This focus is enhanced by a multidisciplinary core of didactic seminars, journal clubs and formal coursework that are designed for each trainee through consultation with the mentor/program administrators to provide individualized education in key aspects of cardiopulmonary development and disease. Our objectives are: 1) to provide extensive mentoring to the trainee for career development and for developing independent research plans that focus on pediatric diseases; 2) to promote training in basic cell and molecular biology, genomics, and bioinformatics together with clinical translational research; and 3) to guide our trainees’ development so that, after the completion of training, successful competition for independent funding is likely.