Pilot Feasibility Program

试点可行性研究项目总结 我们德克萨斯医疗中心消化疾病中心（DDC）最重要的项目之一是试点 可行性（P/F）计划。P/F计划的目标是提供试点资金，以（1）支持年轻人 开始消化系统疾病（DD）研究职业生涯的研究人员;（2）促进DD相关研究的发展 由德克萨斯医学中心的初级和成熟研究者在非DD相关领域进行的研究。这些 目标是通过支持科研人员发起的科学研究来实现的， 研究项目。补充DDC目标的研究DD相关主题的新方法包括 鼓励。奖项是在严格的同行评审过程中授予的，包括对以下方面的评估： 科学审查委员会的科学价值，其中包括DDC内部咨询委员会成员， 来自德克萨斯医学中心的特设科学家和DDC外部咨询委员会成员。 我们要求每年10万美元，以继续P/F计划。这一资金大大增加， 我们的三个合作机构的额外年度承诺，包括来自牛津大学的25，000美元 德克萨斯州健康科学中心（UTHSC），德克萨斯大学医学博士25，000美元安德森癌症中心 （MDACC）和贝勒医学院（Baylor College of Medicine）的11.5万美元。所有P/F获奖者均可优先使用我们的 核心为1年或其奖励的持续时间。 P/F计划有着良好的成就记录。在过去10年，我们支持了71个P/F 受助人，其中36人已集体获得49 313 693美元的校外直接成本资金， 成功率为51%，DDC基金的投资回报率为24倍。 从2018年到2022年，我们每年收到11至27份申请（平均19份）。对于2022年的资金，我们 收到20份意向书，完成11份申请供审查。最重要的四个建议被描述 在这个应用程序中，以说明DDC激励和促进的新研究的广度和质量。 P/F计划有一名主任和两名助理主任，代表三个伙伴机构（教育部， UTHSC、MDACC）和科学审查委员会。我们有几个正式的招揽流程， 审查P/F提案。审查考虑因素包括项目新奇、可行性、资格、申请人 生产力，并与我们的DDC主题保持一致，该项目将导致新知识和 校外资金和DDC核心的使用我们的P/F计划与我们的儿科和成人DD培训相结合 职业发展计划向所有DDC成员开放，帮助招募新的教师和培养 所有DDC成员之间的协作和多学科互动。

PILOT FEASIBILITY PROGRAM PROJECT SUMMARY One of the most important programs of our Texas Medical Center Digestive Diseases Center (DDC) is the Pilot and Feasibility (P/F) Program. The goals of the P/F Program are to provide pilot funds to (1) support young investigators starting a career in digestive disease (DD) research and (2) foster the development of DD-related research by both junior and established investigators in non-DD related fields in the Texas Medical Center. These goals are accomplished by supporting investigator-initiated scientific studies to generate preliminary data for new research projects. Novel approaches for studying DD-related topics that complement the DDC’s goals are encouraged. Awards are granted following a rigorous peer-review process that involves an evaluation for scientific merit by a Scientific Review Committee, which includes DDC Internal Advisory Committee members, ad hoc scientists from the Texas Medical Center, and DDC External Advisory Committee members. We are requesting $100,000/year to continue the P/F Program. This funding is significantly enhanced by additional annual commitments from our three partner institutions, including $25,000 from The University of Texas Health Science Center (UTHSC), $25,000 from The University of Texas M.D. Anderson Cancer Center (MDACC) and $115,000 from Baylor College of Medicine (BCM). All P/F awardees have priority access to our Cores for 1 year or for the duration of their award. The P/F Program has a strong record of accomplishments. In the past 10 years, we have supported 71 P/F recipients, 36 of whom have collectively been awarded $49,313,693 in extramural direct cost funding, representing a 51% success rate and a 24-fold return on investment of DDC funds. From 2018 to 2022, we received between 11 and 27 applications per year (average 19). For 2022 funding, we received 20 letters of intent, and 11 applications were completed for review. The top four proposals are described in this application to illustrate the breadth and quality of the new research stimulated and facilitated by the DDC. The P/F program has a Director and two Assistant Directors, representing the three partner institutions (BCM, UTHSC, MDACC), and a Scientific Review Committee. We have several formal processes for soliciting and reviewing P/F proposals. Review considerations include project novelty, feasibility, qualifications, applicant productivity, and alignment to our DDC theme, the likelihood the project will lead to new knowledge and extramural funding, and use of our DDC Cores. Our P/F Program coupled with our pediatric and adult-DD training programs with career-development initiatives open to all DDC members help recruit new faculty and foster collaborative, multidisciplinary interactions among all DDC members.