FASEB's The Reproductive Aging Conference

项目总结 我们正在申请资金以支持2021年成立的美国实验学会联合会 生物学(FASE B)生殖老龄化大会，将在Omni Ranco拉斯帕尔马斯度假村(Palm)举行 美国加利福尼亚州斯普林斯)，2021年5月23日至27日。性腺的衰老极大地影响躯体的衰老 组织，但我们对调节生殖器官健康衰老的机制知之甚少，也不知道这是如何 实现了串扰。本次首届会议将聚焦于了解调节衰老的机制。 生殖组织及其与整体生物体健康和寿命的关系。基金是 被要求帮助支付1)特邀演讲者和2)功勋初级科学家(学生， 博士后研究员和初级教员)和将受益于正式和非正式培训的少数族裔受训人员 与资深科学家互动，介绍他们的研究成果，接受该领域专家的反馈， 并就塑造这一领域交换意见。据我们所知，这将是第一次国际会议。 完全致力于生殖衰老的主题。FASE B生殖老龄化会议的目标是 展示研究并鼓励合作，架起生殖生物学和老龄化学科之间的桥梁 进行研究，帮助确定新的范式，以加快进展。我们的首要目标是成为 联合领域和促进对概念的讨论和研究报告的论坛 发现与生殖系统衰老有关的前沿及其与其余部分衰老的联系 尸体。生殖衰老研究包括多个感兴趣的方面：识别分子和 调节生殖器官衰老的细胞机制，促进整体健康和长寿； 生殖细胞和生态位衰老的机制以及它们如何调节系统衰老；以及发展新的 研究这些相互作用的模型。这些历史上分离的地区的交集，基本的生物学 衰老和生殖道中的衰老，已经开始围绕共同的分子原理合并。受邀 演讲者包括知名的和杰出的早期职业科学家，他们是根据他们的质量而被挑选出来的 科学和激发辩论的能力。这次会议将为正式和非正式会议提供一个论坛 学员和教职员工在各个阶段的互动，以促进思想交流和协作 围绕生殖老龄化的协同效应。海报和口头演示文稿将在 分子、细胞和生物体水平，包括其分子驱动因素，以及遗传和 环境因素对不同模型系统中相关细胞/系统属性和相互作用的影响 从蠕虫到人类。这一独特的会议将把研究这一问题的科学家从 基础的临床角度，头脑风暴的创造性方法，以建立和加强该领域。

PROJECT SUMMARY We are requesting funds to support the Inaugural 2021 Federation of American Societies for Experimental Biology (FASEB) Reproductive Aging Conference, to be held at the Omni Rancho Las Palmas Resort (Palm Springs, California, USA) on May 23 - 27, 2021. Aging in the gonad dramatically affects aging in somatic tissues, yet we know little about the mechanisms regulating healthy aging in reproductive organs, nor how this crosstalk is achieved. This inaugural conference will focus on understanding mechanisms that regulate aging in reproductive tissues and their relationship to overall organismal healthspan and longevity. Funds are requested to help cover expenses of 1) invited speakers and 2) meritorious junior scientists (students, postdoctoral fellows and junior faculty) and minority trainees who will benefit from formal and informal interactions with senior scientists, to present their research findings, receive feedback from experts in the field, and exchange ideas for shaping the field. To our knowledge, this will be the first international meeting dedicated entirely to the topic of reproductive aging. The goal of the FASEB Reproductive Aging conference is to showcase research and stimulate collaborations that bridge the disciplines of reproductive biology and aging research to help define new paradigms to accelerate progress. Our primary objective is to become the premier forum for coalescing the field and fostering the discussion of concepts and presentation of research at the forefront of discovery related to aging in the reproductive system and its connection to aging in the rest of the body. Reproductive aging research encompasses multiple fronts of interest: identification of the molecular and cellular mechanisms that regulate aging in reproductive organs that facilitate overall healthspan and longevity; mechanisms of germ cell and niche aging and how these might regulate systemic aging; and developing new models to study these interactions. The intersection of these historically separate areas, the basic biology of aging and aging in the reproductive tract, have begun to merge around common molecular principles. Invited speakers include established as well as outstanding early career scientists selected for the quality of their science and ability to stimulate debate. This conference will provide a forum for both formal and informal interactions between trainees and faculty at all stages to promote the exchange of ideas and collaborative synergies around reproductive aging. Poster and oral presentations will examine reproductive aging at the molecular, cellular and organismal level, including its molecular drivers, and the effects of genetic and environmental factors on relevant cellular/system properties and interactions across diverse model systems ranging from worms to humans. This unique conference will bring together scientists tackling this problem from fundamental to clinical angles to brainstorm creative ways to build and strengthen the field.