The Reproductive Aging Conference

项目摘要 我们正在申请资金，以支持生殖老龄化会议每年3年，2023 - 2025年。 2023年会议将于5月5日在Omni Rancho Las帕尔马斯度假村（美国加州棕榈泉）举行 2023年2月5日这将是2022年6月成立大会后的第二次会议。老龄化 性腺对体细胞组织的衰老有着显著的影响，但我们对性腺的调节机制知之甚少。 生殖器官的健康老化，也不知道这种串扰是如何实现的。生殖衰老会议 将侧重于了解调节生殖组织衰老的机制及其与 整体生物体的健康寿命和寿命。每年都需要资金来帮助支付以下费用： 特邀演讲人和2）有价值的年轻科学家（学生，博士后研究员和年轻教师）， 少数民族学员将受益于与资深科学家的正式和非正式互动， 研究成果，从该领域的专家那里获得反馈，并为塑造该领域交换意见。对我们 这是唯一一次专门讨论生殖老化问题的国际会议。 生殖衰老会议的目标是展示研究和促进合作， 连接生殖生物学和衰老研究的学科，以帮助定义新的范式， 中求进工作总我们的主要目标是成为联合该领域和促进 讨论概念和介绍研究的最前沿发现有关老龄化在 生殖系统及其与身体其他部位衰老的联系。生殖老化研究 包括多个感兴趣的方面：鉴定调节的分子和细胞机制， 生殖器官老化，促进整体健康和长寿;生殖细胞和 生态位衰老以及这些可能如何调节系统性衰老;并开发新的模型来研究这些 交互.这些历史上分离的领域的交叉点，衰老和衰老的基本生物学， 生殖道，已经开始围绕共同的分子原理融合。受邀演讲嘉宾包括 建立以及杰出的早期职业科学家选择他们的科学和能力的质量， 激发辩论。本次会议将为以下各方提供一个正式和非正式互动的论坛： 学员和教师在各个阶段，以促进思想交流和协作协同作用，围绕 生殖老化海报和口头报告将研究生殖老化的分子，细胞， 和生物体水平，包括其分子驱动因素，以及遗传和环境因素对 相关的细胞/系统属性和跨不同模型系统的交互，从蠕虫到 人类这个独特的会议将汇集科学家解决这个问题，从基础到临床 从不同的角度来集思广益，创造性地建立和加强该领域。

PROJECT SUMMARY We are requesting funds to support the Reproductive Aging Conference annually for 3 years, 2023 - 2025. The 2023 meeting will be held at the Omni Rancho Las Palmas Resort (Palm Springs, California, USA) on May 2 - 5, 2023. This will be the second meeting following the Inaugural conference in June 2022. Aging in the gonad dramatically affects aging in somatic tissues, yet we know little about the mechanisms regulating healthy aging in reproductive organs, nor how this crosstalk is achieved. The Reproductive Aging conference will focus on understanding mechanisms that regulate aging in reproductive tissues and their relationship to overall organismal healthspan and longevity. Funds are requested each year to help cover expenses of 1) invited speakers and 2) meritorious junior scientists (students, postdoctoral fellows and junior faculty) and minority trainees who will benefit from formal and informal interactions with senior scientists, to present their research findings, receive feedback from experts in the field, and exchange ideas for shaping the field. To our knowledge, this is the only international meeting dedicated entirely to the topic of reproductive aging. The goal of the Reproductive Aging conference is to showcase research and stimulate collaborations that bridge the disciplines of reproductive biology and aging research to help define new paradigms to accelerate progress. Our primary objective is to become the premier forum for coalescing the field and fostering the discussion of concepts and presentation of research at the forefront of discovery related to aging in the reproductive system and its connection to aging in the rest of the body. Reproductive aging research encompasses multiple fronts of interest: identification of the molecular and cellular mechanisms that regulate aging in reproductive organs that facilitate overall healthspan and longevity; mechanisms of germ cell and niche aging and how these might regulate systemic aging; and developing new models to study these interactions. The intersection of these historically separate areas, the basic biology of aging and aging in the reproductive tract, have begun to merge around common molecular principles. Invited speakers include established as well as outstanding early career scientists selected for the quality of their science and ability to stimulate debate. This conference will provide a forum for both formal and informal interactions between trainees and faculty at all stages to promote the exchange of ideas and collaborative synergies around reproductive aging. Poster and oral presentations will examine reproductive aging at the molecular, cellular and organismal level, including its molecular drivers, and the effects of genetic and environmental factors on relevant cellular/system properties and interactions across diverse model systems ranging from worms to humans. This unique conference will bring together scientists tackling this problem from fundamental to clinical angles to brainstorm creative ways to build and strengthen the field.