The Reproductive Aging Conference

项目总结 我们正在申请资金，在2023-2025年的三年内每年支持生殖老龄化大会。 2023年会议将于5月在美国加利福尼亚州棕榈泉的欧姆兰乔·拉斯帕尔马斯度假村举行 2023年2胜5负。这将是继2022年6月就职大会之后的第二次会议。中国的老龄化 性腺极大地影响身体组织的衰老，但我们对其调节机制知之甚少。 生殖器官的健康衰老，也不知道这种相声是如何实现的。生殖老龄化大会 将侧重于了解调节生殖组织衰老的机制及其与 整体生物体的健康寿命和寿命。每年申请资金以帮助支付1)的费用 特邀演讲人和功勋卓著的初级科学家(学生、博士后研究员和初级教员)和 将从与资深科学家的正式和非正式互动中受益的少数族裔受训人员，介绍他们的 研究成果，接受该领域专家的反馈，并就塑造该领域交换意见。致我们的 知识，这是唯一一个专门讨论生殖老龄化问题的国际会议。 生殖老龄化大会的目标是展示研究并鼓励合作， 在生殖生物学和衰老研究的学科之间架起桥梁，以帮助定义新的范式以加速 进步。我们的主要目标是成为联合这一领域并促进 讨论与老龄化相关的最前沿研究的概念和介绍 生殖系统及其与身体其他部位衰老的联系。生殖衰老研究 包含多个感兴趣的前沿：识别调节 促进整体健康和长寿的生殖器官中的衰老；生殖细胞和 生态位老化及其如何调节全身衰老；以及开发新的模型来研究这些 互动。这些历史上分离的领域的交集，老龄化和老龄化的基本生物学 生殖道，已经开始围绕共同的分子原理融合。特邀演讲者包括 公认的和杰出的早期职业科学家是根据他们的科学质量和能力而被挑选出来的 激发辩论。本次会议将为双方的正式和非正式互动提供一个论坛 学员和教职员工在各个阶段促进思想交流和协同增效 生殖衰老。海报和口头演示将在分子、细胞 和生物水平，包括其分子驱动因素，以及遗传和环境因素对 相关的细胞/系统属性和跨不同模型系统的交互作用，从蠕虫到 人类。这次独特的会议将把科学家们聚集在一起，从基础到临床研究这一问题。 以集思广益的方式来建设和加强这一领域。

PROJECT SUMMARY We are requesting funds to support the Reproductive Aging Conference annually for 3 years, 2023 - 2025. The 2023 meeting will be held at the Omni Rancho Las Palmas Resort (Palm Springs, California, USA) on May 2 - 5, 2023. This will be the second meeting following the Inaugural conference in June 2022. Aging in the gonad dramatically affects aging in somatic tissues, yet we know little about the mechanisms regulating healthy aging in reproductive organs, nor how this crosstalk is achieved. The Reproductive Aging conference will focus on understanding mechanisms that regulate aging in reproductive tissues and their relationship to overall organismal healthspan and longevity. Funds are requested each year to help cover expenses of 1) invited speakers and 2) meritorious junior scientists (students, postdoctoral fellows and junior faculty) and minority trainees who will benefit from formal and informal interactions with senior scientists, to present their research findings, receive feedback from experts in the field, and exchange ideas for shaping the field. To our knowledge, this is the only international meeting dedicated entirely to the topic of reproductive aging. The goal of the Reproductive Aging conference is to showcase research and stimulate collaborations that bridge the disciplines of reproductive biology and aging research to help define new paradigms to accelerate progress. Our primary objective is to become the premier forum for coalescing the field and fostering the discussion of concepts and presentation of research at the forefront of discovery related to aging in the reproductive system and its connection to aging in the rest of the body. Reproductive aging research encompasses multiple fronts of interest: identification of the molecular and cellular mechanisms that regulate aging in reproductive organs that facilitate overall healthspan and longevity; mechanisms of germ cell and niche aging and how these might regulate systemic aging; and developing new models to study these interactions. The intersection of these historically separate areas, the basic biology of aging and aging in the reproductive tract, have begun to merge around common molecular principles. Invited speakers include established as well as outstanding early career scientists selected for the quality of their science and ability to stimulate debate. This conference will provide a forum for both formal and informal interactions between trainees and faculty at all stages to promote the exchange of ideas and collaborative synergies around reproductive aging. Poster and oral presentations will examine reproductive aging at the molecular, cellular and organismal level, including its molecular drivers, and the effects of genetic and environmental factors on relevant cellular/system properties and interactions across diverse model systems ranging from worms to humans. This unique conference will bring together scientists tackling this problem from fundamental to clinical angles to brainstorm creative ways to build and strengthen the field.